Management of Osteoporosis in CKD

Clinical Journal of the American Society of Nephrology : CJASN
Pascale Khairallah, Thomas L Nickolas

Abstract

CKD mineral and bone disease is a common complication of kidney disease, and it affects the majority of patients with moderate to severe CKD. Recently, prospective studies have shown that measurement of bone mineral density by dual energy x-ray absorptiometry predicts incident fracture, providing nephrologists the ability to risk classify patients for skeletal fragility and targeted antifracture strategies for the first time. Furthermore, an expanding body of literature and anecdotal evidence suggest that pharmacologic agents used to treat osteoporosis in the general population can be safely used in patients with CKD. This review highlights the effects of the Kidney Disease Improving Global Outcomes updates on the management of CKD-associated osteoporosis, discusses recent investigations on the effects of antiosteoporotic agents in patients with CKD, and provides an overview of novel antiosteoporosis agents and the potential challenges related to their use in CKD.

References

Jul 8, 2000·Kidney International·A M AlemC Stehman-Breen
May 15, 2002·Mayo Clinic Proceedings·Lorraine A Fitzpatrick
Jul 5, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Sidney KlawanskySusan D Ross
Sep 17, 2005·Kidney International·Giorgio CoenErmanno Bonucci
Nov 19, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul D MillerDavid E Burgio
Sep 29, 2006·Journal of the American Society of Nephrology : JASN·Thomas L NickolasElizabeth Shane
Oct 3, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P D MillerJ H Krege
Jan 25, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sophie A JamalSteven R Cummings
Mar 14, 2008·Kidney International·D L Andress
Aug 13, 2009·The New England Journal of Medicine·Steven R CummingsUNKNOWN FREEDOM Trial
Aug 21, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sankar D NavaneethanGiovanni F M Strippoli
Oct 15, 2009·JAMA : the Journal of the American Medical Association·Carmen A BrauerAllison B Rosen
Mar 30, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Nigel D ToussaintPeter G Kerr
Jun 17, 2010·Molecular & Cellular Proteomics : MCP·Athanasios DidangelosManuel Mayr
Jul 1, 2010·Kidney & Blood Pressure Research·Daniel CejkaMartin Haas
Sep 30, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Praveen KandulaSankar D Navaneethan
Apr 15, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sophie A JamalPaul D Miller
Jun 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Soichiro IimoriYusuke Tsukamoto
Nov 22, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sarah L WestCharmaine E Lok
Mar 31, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Geoffrey A BlockDesmond Padhi
Apr 21, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Robert H YenchekUNKNOWN Health, Aging, and Body Composition Study
May 2, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Thomas J ArnesonWendy L St Peter
May 11, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Sumi Sukumaran NairWolfgang C Winkelmayer
Jun 8, 2013·Journal of the American Society of Nephrology : JASN·Anne C BeaubrunM Alan Brookhart
Oct 1, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·John WagnerSteven Fishbane
Jan 3, 2014·The New England Journal of Medicine·Michael R McClungHenry G Bone
Mar 29, 2014·The Journal of Clinical Endocrinology and Metabolism·Chien-Liang ChenJenn-Huei Renn
Jun 28, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Daniel W CoyneStuart M Sprague
Sep 4, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F CosmanR Lindsay
Nov 14, 2014·The Journal of Clinical Endocrinology and Metabolism·Benjamin Z LederGary Hattersley
Nov 18, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sarah L WestSophie A Jamal
Dec 17, 2014·Journal of the American Society of Nephrology : JASN·Sharon M MoeUNKNOWN Evaluation of Cinacalcet HCl Therapy to Lower Cardiovascular Events (EVOLVE) Trial Investigators
Feb 7, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Kyla L NaylorSophie A Jamal
Nov 4, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K SumidaK Takaichi
Dec 17, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Leena PatelGrahame J Elder
Oct 21, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sun Moon KimGlenn M Chertow
Jul 11, 2016·Journal of Nephrology·Francescaromana FestucciaPaolo Menè
Aug 18, 2016·JAMA : the Journal of the American Medical Association·Paul D MillerUNKNOWN ACTIVE Study Investigators
Nov 1, 2016·The New England Journal of Medicine·Felicia CosmanAndreas Grauer
Dec 10, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M OtaN Iwasaki

❮ Previous
Next ❯

Citations

Jan 30, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K S Bezerra de CarvalhoR M Elias
Jan 5, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H McKeeJ D Adachi
Nov 2, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ludmila BrunerovaSylvie Dusilova Sulkova
Oct 31, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pascale KhairallahMaria Fusaro
Mar 3, 2020·The Journal of Nutrition, Health & Aging·Y TabaraM Igase
Jul 1, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julie BernardorJustine Bacchetta
Sep 24, 2020·International Journal of Molecular Sciences·Chia-Yu HsuKuo-Hu Chen
Apr 28, 2019·International Journal of Molecular Sciences·Hung-Wei LiaoKuen-Jer Tsai
Oct 25, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pieter EvenepoelUNKNOWN European Renal Osteodystrophy (EUROD) workgroup, an initiative of the CKD-MBD working group of the ERA-EDTA, and the committ
Nov 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Aaron BroadwellPaul D Miller
Dec 20, 2020·Pediatric Transplantation·Kirstin KusumiJohn D Mahan
Nov 18, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Adrien NizetPer Magnusson
Feb 4, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaNikoleta Printza
Jan 6, 2021·Calcified Tissue International·Jordi BoverCarlos Gómez-Alonso
Feb 19, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K KimY K Jeon
Jul 13, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Merav BarPaul A Carpenter
Apr 1, 2021·Renal Failure·Hao-Yang MaYang Du
Mar 29, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael Pazianas, Paul D Miller
Mar 28, 2021·Calcified Tissue International·Ana Carina FerreiraUNKNOWN European Renal Osteodystrophy (EUROD), an initiative of the CKD-MBD working group of the ERA-EDTA
Jun 16, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Pascale Khairallah, Thomas L Nickolas
Nov 4, 2021·Current Osteoporosis Reports·Orlando M Gutiérrez
Nov 6, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Hao-Yang MaAi-Hua Zhang
Nov 1, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Minako WakasugiIchiei Narita
Jan 18, 2022·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rose M Ayoob, John D Mahan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Osteoporosis Reports
S A Jamal, Thomas L Nickolas
Clinical Journal of the American Society of Nephrology : CJASN
Robert H YenchekHealth, Aging, and Body Composition Study
© 2022 Meta ULC. All rights reserved