Management of pancreatic cancer in the elderly

World Journal of Gastroenterology : WJG
Oliver HigueraJaime Feliu

Abstract

Currently, pancreatic adenocarcinoma mainly occurs after 60 years of age, and its prognosis remains poor despite modest improvements in recent decades. The aging of the population will result in a rise in the incidence of pancreatic adenocarcinoma within the next years. Thus, the management of pancreatic cancer in the elderly population is gaining increasing relevance. Older cancer patients represent a heterogeneous group with different biological, functional and psychosocial characteristics that can modify the usual management of this disease, including pharmacokinetic and pharmacodynamic changes, polypharmacy, performance status, comorbidities and organ dysfunction. However, the biological age, not the chronological age, of the patient should be the limiting factor in determining the most appropriate treatment for these patients. Unfortunately, despite the increased incidence of this pathology in older patients, there is an underrepresentation of these patients in clinical trials, and the management of older patients is thus determined by extrapolation from the results of studies performed in younger patients. In this review, the special characteristics of the elderly, the multidisciplinary management of localized and advance...Continue Reading

References

Apr 1, 1990·Journal of the American Geriatrics Society·B A FerrellD Osterweil
Jun 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H A BurrisD D Von Hoff
Dec 8, 1998·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·T A SohnH A Pitt
Dec 30, 1999·The New England Journal of Medicine·L F HutchinsK S Albain
Feb 19, 2000·Hematology/oncology Clinics of North America·L Balducci, M Extermann
Jul 8, 2000·The Oncologist·L Balducci, M Extermann
Feb 15, 2002·Journal of the American Geriatrics Society·D SalibaN S Wenger
May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Hiroyuki ShinchiTakashi Aikou
Sep 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monika K KrzyzanowskaCraig C Earle
Mar 19, 2004·The New England Journal of Medicine·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Mar 31, 2004·Lancet·Donghui LiJames L Abbruzzese
Apr 28, 2004·Seminars in Oncology·Rosemary Yancik, Lynn A G Ries
Nov 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lilia TalaricoRichard Pazdur
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C LouvetUNKNOWN GISCAD
Jul 16, 2005·Oncology·Chigusa MorizaneHiroshi Ikeda
Mar 1, 2006·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Martin A MakaryCharles J Yeo
Apr 26, 2006·The American Journal of Gastroenterology·Frédérique MairePhilippe Ruszniewski
Jun 10, 2006·The American Journal of Clinical Nutrition·Kenneth C FearonUNKNOWN Cancer Cachexia Study Group
Jul 26, 2006·Annals of Surgical Oncology·Gauri R VaradhacharyRobert A Wolff
Feb 28, 2007·Journal of the American College of Surgeons·Thomas A AloiaPeter W T Pisters
Apr 25, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm J MooreUNKNOWN National Cancer Institute of Canada Clinical Trials Group
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine BouchardyGeorges Vlastos
Jun 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard HerrmannUNKNOWN Central European Cooperative Oncology Group
Jun 15, 2007·BMC Gastroenterology·Suzanne M JeurninkPeter D Siersema
Nov 24, 2007·Journal of the American College of Surgeons·Emily FinlaysonJohn D Birkmeyer
Apr 1, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K C H Fearon
Apr 5, 2008·Journal of the American College of Surgeons·Robert A MeguidDavid C Chang
May 13, 2008·Journal of the American College of Surgeons·Matthew H G KatzRosa F Hwang
Jan 2, 2009·Cancer·Daniel T ChangAlbert C Koong
Jan 6, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alberto QuagliaUNKNOWN EUROCARE Working Group
Oct 6, 2009·International Journal of Radiation Oncology, Biology, Physics·David T MiyamotoTheodore S Hong
Oct 23, 2009·Advances in Surgery·Taylor S Riall
Oct 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David CunninghamJohn P Neoptolemos
Jan 9, 2010·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Angela Grimes, Sathees B C Chandra
Mar 24, 2010·American Journal of Clinical Oncology·Jean-Claude M RwigemaSteven A Burton
Jul 21, 2010·International Journal of Radiation Oncology, Biology, Physics·David P HorowitzJoseph M Herman
Sep 9, 2010·JAMA : the Journal of the American Medical Association·John P NeoptolemosUNKNOWN European Study Group for Pancreatic Cancer
Apr 2, 2011·Journal of the American Geriatrics Society·Taylor S RiallJames S Goodwin
May 13, 2011·The New England Journal of Medicine·Thierry ConroyUNKNOWN PRODIGE Intergroup
Jul 12, 2011·The Lancet Oncology·Judith Lees, Alexandre Chan

❮ Previous
Next ❯

Citations

Apr 5, 2016·Journal of Surgical Oncology·Daniel E Abbott
Aug 6, 2016·Current Oncology Reports·Shin Yin LeeKevan L Hartshorn
Mar 28, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Amber Draper
Nov 11, 2017·Expert Review of Anticancer Therapy·Yusuf KarakasSuayib Yalcin
Apr 5, 2019·Journal of Hepato-biliary-pancreatic Sciences·Yutong GaoJing Dai
Jun 28, 2020·Journal of Clinical Laboratory Analysis·Cui Xu, Xiangxiu Qi
Mar 12, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Chao-Ming TsengYao-Chun Hsu
May 11, 2020·Annals of Surgical Oncology·Jesse V GroenUNKNOWN Dutch Pancreatic Cancer Group
Jul 25, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Qinyu ChenTimothy M Pawlik
Sep 20, 2017·Journal of Gastrointestinal Cancer·Pedro L S Usón JuniorFernando C Maluf
Jun 16, 2018·International Journal of Molecular Sciences·Lian-Yu ChenZhen Chen
May 3, 2019·Middle East Journal of Digestive Diseases·Sahar MasoudiAshraf Mohamadkhani
Jan 3, 2021·Current Oncology Reports·Ammoren DohmRonica H Nanda
Dec 15, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·L J H BradaUNKNOWN Dutch Pancreatic Cancer Group
Dec 8, 2020·Therapeutic Advances in Gastroenterology·Hasan RehmanMuhammad Wasif Saif
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Chao-Ming TsengYao-Chun Hsu
Mar 15, 2020·The Surgical Clinics of North America·Alexander S RosemurgyIswanto Sucandy
Apr 24, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Hemanth K KandikattuAnil Mishra
Apr 6, 2021·Artificial Organs·Mitsuyoshi OkazakiTetsuo Ohta
Oct 2, 2021·Current Treatment Options in Oncology·Arthur Winer, Efrat Dotan
Jul 7, 2021·Journal of Geriatric Oncology·Ana Raquel MonteiroLissandra Dal Lago

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