Management of patients with essential thrombocythemia: current concepts and perspectives

Pathologie-biologie
Jean Briere, F Guilmin

Abstract

Essential thrombocythemia must now be regarded as a heterogeneous disease. Recent availability of clonality studies have repeatedly shown that a significant number of female patients diagnosed as E.T. according the most stringent criteria had a definitely polyclonal myelopoiesis. Although the incidence of patients newly diagnosed every year is low, there is in fact a conspicuous population of E.T., followed as outpatients in every department of hematology or internal medicine, including a large number of young females. These eventualities should be integrated in further discussions of the benefit/risk ratio of cytoreduction with the presently available drugs. The combination of several evidence-based data is the basis of a widely accepted stratification of high-risk patients defined by any of the following features. Age > 60 to 65. History of thrombosis or embolic or major ischemic events. Platelet counts in excess of 1000 or 1500 x 10(9)/L. In the question of chemotherapy in E.T., growing concern comes from the potential leukemogenic risk associated with the presently available drugs and extends beyond Melphalan, Busulfan and other alkylating agents and includes non-alkylating agents like Hydroxyurea. At the same time, much at...Continue Reading

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Citations

May 20, 2015·Platelets·Rafał MałeckiAnetta Undas
Dec 6, 2006·The Journal of Veterinary Medical Science·Takeshi MizukoshiTetsuya Shimoda
Jan 15, 2015·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·John BriereColin Dias
Aug 22, 2007·Eating Disorders·John Briere, Catherine Scott
Jun 15, 2011·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Michelle M Lilly
Dec 2, 2006·Drugs·Elisabeth I Penninga, Ole W Bjerrum
Nov 29, 2007·The Journal of Nervous and Mental Disease·Martine HébertMireille Cyr
May 31, 2020·Molecular Biology Reports·Mohsen MalekniaNajmaldin Saki
Feb 16, 2006·The Journal of Nervous and Mental Disease·John Briere
Jun 15, 2007·The Journal of Nervous and Mental Disease·John Briere, Shannae Rickards

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