Management of patients with hepatocellular carcinoma and portal vein tumour thrombosis: comparing east and west

The Lancet. Gastroenterology & Hepatology
Jian LuGao-Jun Teng

Abstract

Portal vein tumour thrombosis is common among patients with advanced hepatocellular carcinoma. Tremendous differences exist in the management of hepatocellular carcinoma with portal vein tumour thrombosis between the east and the west, which derive from heterogeneities in its epidemiology, causes, pathology, comorbidities, prognosis, and other demographics. These divergences between the east and the west are not only caused by hepatocellular carcinoma itself, but are also affected by many variables including social factors, physician preferences, accessibility to costly or novel treatments, and reimbursement schemes. In this Review, we compare and contrast the management of hepatocellular carcinoma with portal vein tumour thrombosis in the east and in the west in terms of systemic and surgical treatments, radiotherapy, transcatheter arterial therapies, and portal vein revascularisation. We conclude that a personalised, data-driven approach to care with active management from a multidisciplinary team, as well as increased communication and collaboration between clinicians and researchers based in east and the west, could help to reduce the differences in management and optimise treatment strategies.

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Citations

Sep 15, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shun KanekoNamiki Izumi
Sep 20, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shin HwangSung-Gyu Lee
Jul 24, 2020·World Journal of Gastrointestinal Oncology·Bao-Jiang LiuRen-Jie Yang
Feb 18, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alessandro VitaleUmberto Cillo
Jun 29, 2021·Frontiers in Oncology·Bin LiWeijia Fang
Jun 13, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mingming JinGang Huang
Mar 6, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiu-Ping ZhangRong Liu
Sep 8, 2021·Journal of Cancer Research and Clinical Oncology·So Jung LeeHye Jin Kang

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