Management of Patients With High Baseline Hip Fracture Risk by FRAX Reduces Hip Fractures-A Post Hoc Analysis of the SCOOP Study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
E McCloskeySCOOP Study Team

Abstract

The Screening for Osteoporosis in Older Women for the Prevention of Fracture (SCOOP) study was a community-based screening intervention in women aged 70 to 85 years in the United Kingdom. In the screening arm, licensed osteoporosis treatments were recommended in women identified to be at high risk of hip fracture using the FRAX risk assessment tool (including bone mineral density measurement). In the control arm, standard care was provided. Screening led to a 28% reduction in hip fractures over 5 years. In this planned post hoc analysis, we wished to examine for interactions between screening effectiveness on fracture outcome (any, osteoporotic, and hip fractures) on the one hand and baseline FRAX 10-year probability of hip fracture on the other. All analyses were conducted on an intention-to-treat basis, based on the group to which women were randomized, irrespective of whether screening was completed. Of 12,483 eligible participants, 6233 women were randomized to screening, with treatment recommended in 898 (14.4%). No evidence of an effect or interaction was observed for the outcomes of any fracture or osteoporotic fracture. In the screening arm, 54 fewer hip fractures were observed than in the control arm (164 versus 218, 2...Continue Reading

References

Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE McCloskey
Nov 13, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E V McCloskeyJ A Kanis
Feb 3, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisE V McCloskey
Feb 9, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L ShepstoneE McCloskey
Mar 21, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eugene V McCloskeyJohn A Kanis
Jun 21, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N C HarveyE V McCloskey
Jun 21, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N C HarveyE V McCloskey
Nov 14, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E McCloskey
Jul 29, 2016·Archives of Osteoporosis·John A KanisUNKNOWN Advisory Board of the National Osteoporosis Guideline Group
Feb 9, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N C W HarveyJ A Kanis
Apr 21, 2017·Archives of Osteoporosis·J CompstonUNKNOWN National Osteoporosis Guideline Group (NOGG)
Apr 30, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)
May 6, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eugene V McCloskeyJohn A Kanis

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Citations

Nov 2, 2018·Archives of Osteoporosis·John A KanisEugene V McCloskey
Feb 20, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maria PisuTony M Keaveny
Feb 12, 2020·Aging Clinical and Experimental Research·John A KanisEugene V McCloskey
Feb 28, 2020·Current Osteoporosis Reports·Elizabeth M CurtisNicholas C Harvey
Mar 12, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Felicia Cosman
Sep 27, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W D Leslie
Apr 14, 2019·Journal of Endocrinological Investigation·J LiuN C Harvey
Jun 14, 2019·Nature Reviews. Endocrinology·Nicholas R FuggleCyrus Cooper
Apr 15, 2020·Current Osteoporosis Reports·William D Leslie, Suzanne N Morin
Jun 23, 2019·Archives of Osteoporosis·Pojchong ChotiyarnwongEugene V McCloskey
Jan 22, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C I ConduracheUNKNOWN SCOOP Study Team
Oct 14, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C M ParsonsUNKNOWN SCOOP Trial Group
Oct 17, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committe
Feb 23, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R J HollickA J Black
Oct 16, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E V McCloskeyJ A Kanis
Dec 29, 2020·Bone·Nicholas R FuggleCyrus Cooper
Dec 12, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A M BurdenC C Glüer
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Felicia Cosman
May 6, 2021·Singapore Medical Journal·Eu-Leong Yong, Susan Logan

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