Management of patients with recurrent glioblastoma using hypofractionated stereotactic radiotherapy

Tumori
Ferrat DincoglanBahar Dirican

Abstract

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The chance of cure is very limited due to treatment-refractory disease course with frequent recurrences despite aggressive multimodality management. In this retrospective study, we evaluated treatment outcomes of hypofractionated stereotactic radiotherapy (HFSRT) in the management of recurrent GBM and report our single-center experience. Twenty-eight patients receiving HFSRT for recurrent GBM between September 2008 and February 2014 were retrospectively assessed. Total radiotherapy dose was 25 Gy delivered in 5 fractions over 5 consecutive days for all patients. High-precision, image-guided volumetric modulated arc therapy was delivered with a linear accelerator using 6-MV photons using the frameless technique. Analyzed prognostic factors were age, gender, Karnofsky performance status (KPS), tumor location, planning target volume (PTV) size, overall survival (OS), progression-free survival (PFS), time interval between completion of treatment with Stupp protocol at primary diagnosis and recurrence. Median follow-up time was 42 months (range 2-68). Median time interval between primary chemoradiotherapy and HFSRT was 11.2 months (range 4-57.9). Median O...Continue Reading

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Citations

Aug 21, 2015·Expert Opinion on Investigational Drugs·Jennifer H Kang, Cory Adamson
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Dec 12, 2020·Critical Reviews in Oncology/hematology·Silvia ScocciantiLorenzo Livi

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Methods Mentioned

BETA
surgical resection
biopsy

Software Mentioned

XVI
SimMD
ERGO

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