PMID: 8960512Nov 1, 1996Paper

Management of peripheral vascular disease: innovative approaches using radiation therapy

International Journal of Radiation Oncology, Biology, Physics
D NoriJ Moni

Abstract

Despite the early successes at vascular recanalization with percutaneous transluminal angioplasty, vascular restenosis has emerged as a clinical problem of near epidemic proportions. Numerous pharmacologic and mechanical adjuncts have been tried with little success. Over the last few years, there have major advances in our understanding of the biology of the restenotic process. The process is now recognized as a proliferation disorder, and therapies akin to those used in the treatment of malignant diseases are being explored. Endovascular brachytherapy has shown strong potential in controlling this pathologic proliferative process in the laboratory and in early clinical studies. In this review we discuss some of the basic issues involved in vascular restenosis and the current status of endovascular brachytherapy.

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Citations

Sep 19, 2001·Australasian Physical & Engineering Sciences in Medicine·N BoeingM A Ebert
Jun 9, 1998·Journal of Vascular and Interventional Radiology : JVIR·D A Diamond, T M Vesely
Jan 12, 2002·Cardiovascular Radiation Medicine·J DvorákV Chovanec
Jan 12, 2002·Cardiovascular Radiation Medicine·N S PatelL B Harrison
Nov 9, 2000·Cardiovascular Radiation Medicine·J DvorákJ Fridrich

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