Abstract
Leptomeningeal dissemination of juvenile pilocytic astrocytoma (JPA) is a rare event. We report two children with disseminated JPAs treated with a chemotherapeutic agent, temozolomide, after progression of the disease despite surgery, traditional chemotherapy, and/or radiation therapy. Patient 1 presented with hydrocephalus and progressive lower extremity weakness, and was found to have a suprasellar mass as well as extensive spinal disease. Ventriculoperitoneal shunting, decompressive laminectomy with spinal tumor debulking, and chemotherapy with carboplatin and vincristine were initially employed. However, disease progressed and craniospinal irradiation and temozolomide were used. Patient 1 remains in a fair condition today, 2 years later. Patient 2 presented at 8 months of age with failure to thrive. Imaging revealed a cystic lesion in the hypothalamic region with extensive subarachnoid metastatic disease to the spine. Biopsy was performed followed by chemotherapy with vincristine, cyclohexylchloroethylnitrosourea (CCNU), 6-TG, and procarbazine. Due to the continued progression of the disease, cytoreductive surgery was performed and her chemotherapeutic regimen was switched to temozolomide. Two years after initial presentati...Continue Reading
References
Jan 1, 1978·Journal of Neurosurgery·D C Oxenhandler, M P Sayers
Apr 1, 1976·Neurology·W B WilsonS L Nielsen
Jan 1, 1976·Child's Brain·K Shapiro, K Shulman
Nov 1, 1992·Journal of Neurosurgery·K MishimaN Shitara
Dec 1, 1991·Journal of Neurosurgery·W G ObanaM S Edwards
Mar 1, 1987·Cancer·L WeissR L Dubowy
Apr 1, 1988·Neurology·L A CivitelloL Schut
Jan 1, 1983·Child's Brain·R J PackerL Schut
Jan 1, 1981·Journal of Neurosurgery·R N AuerJ J Gilbert
Jan 1, 1994·Neurosurgery·P B DirksJ T Rutka
Jun 1, 1994·Cancer·M Prados, A N Mamelak
Jun 1, 1994·Cancer·I F PollackA L Albright
Jul 1, 1994·Journal of Neurosurgery·A N MamelakM S Edwards
Sep 1, 1993·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·S NishioM Fukui
Aug 1, 1993·Journal of Neurosurgery·A MoghrabiW J Oakes
May 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J PackerM N Needles
May 15, 1993·Cancer·M T BrownS C Schold
Nov 1, 1995·Clinical Neurology and Neurosurgery·S NishioM Fukui
Oct 1, 1996·Journal of Neuro-oncology·P J SioutosM E Weinand
Jan 1, 1996·Neurosurgical Review·T KayamaT Yoshimoto
Jan 1, 1997·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·C M DirvenW M Molenaar
Jul 1, 1997·Surgical Neurology·M MorikawaH Itoh
Dec 5, 1998·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·M TamuraF Saitoh
Jun 28, 2000·Cancer·P Kleihues, L H Sobin
Sep 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D OsobaM D Prados
Oct 3, 2000·British Journal of Neurosurgery·A B JamjoomM al-Rayess
Apr 13, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M BradaS Zaknoen
Nov 23, 2001·Journal of Neuro-oncology·L E AbreyM G Malkin
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger StuppSerge Leyvraz
Jul 20, 2002·Journal of Neuro-oncology·S TrentM Brada
Citations
Dec 12, 2012·Case Reports in Oncological Medicine·C S AmeneJ R Crawford
Dec 23, 2006·Journal of Neurosurgery·Taylor J AbelAnthony M Avellino
Jan 7, 2011·Brain Tumor Pathology·Keiichi SakaiKazuhiro Hongo
Mar 11, 2016·Journal of Pediatric Neurosciences·Amol RahejaBhawani Shankar Sharma
May 3, 2014·Insights Into Imaging·Danai ChourmouziAntonios Drevelegas
Mar 10, 2012·International Journal of Radiation Oncology, Biology, Physics·Ali MazloomArnold C Paulino
Aug 28, 2015·Pediatric Blood & Cancer·Omar ChamdineIbrahim Qaddoumi
Apr 7, 2018·Journal of Neurosurgery. Pediatrics·Matthew A KirkmanKristian Aquilina
Aug 26, 2006·Current Opinion in Ophthalmology·Grant T Liu
Jul 18, 2009·Journal of Korean Neurosurgical Society·Se Youn JangJohn G Frazee
Mar 28, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Giuseppe BaroneRiccardo Riccardi
Dec 5, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Shelly X BianDavid R Grosshans
Jul 13, 2013·Current Opinion in Ophthalmology·Nandini G Gandhi
Mar 26, 2014·The Oncologist·Deborah A ForstTracy T Batchelor
Jan 13, 2012·Journal of Neuro-oncology·Mark V MishraYaacov Richard Lawrence
Jun 26, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Matthew A KirkmanKristian Aquilina
Oct 13, 2006·Journal of Neuro-oncology·Shoji YomoKazuhiro Hongo
Aug 11, 2007·Journal of Neuro-oncology·Hidehiro TakeiAdekunle M Adesina
Aug 1, 2009·Archives of Pathology & Laboratory Medicine·Peter Pytel, Rimas V Lukas