Management of psychiatric disorders in Parkinson's disease : Neurotherapeutics - Movement Disorders Therapeutics.

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Daniel Weintraub

Abstract

Affective disorders (depression and anxiety), psychosis, impulse control disorders, and apathy are common and sometimes disabling psychiatric conditions in Parkinson disease (PD). Psychiatric aspects of PD are associated with numerous adverse outcomes, yet in spite of this and their high frequency, there remains incomplete understanding of epidemiology, presentation, risk factors, neural substrate, and management strategies. Psychiatric features are typically co- or multimorbid, and there is great intra- and interindividual variability in presentation [1]. The neuropathophysiological changes that occur in PD, as well as the association between PD treatment and particular psychiatric disorders, suggest a neurobiological contribution to many psychiatric symptoms. There is evidence that psychiatric disorders in PD are still under-recognized and undertreated, and although psychotropic medication use is common, randomized controlled trials demonstrating efficacy and tolerability are largely lacking. Future research on neuropsychiatric complications in PD should be oriented toward determining modifiable correlates or risk factors, and most importantly, establishing efficacious and well-tolerated treatment strategies.

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Citations

Jan 3, 2021·Life Sciences·Julliane Vasconcelos Joviano-SantosDanilo Roman-Campos
Jan 17, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Caroline M Tanner, Jill L Ostrem
Feb 2, 2021·Expert Review of Neurotherapeutics·Katarina RukavinaK Ray Chaudhuri
Dec 18, 2020·Frontiers in Psychiatry·Delfina JaniriAnna Rita Bentivoglio

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