Management of pulmonary hypertension in congenital diaphragmatic hernia: nitric oxide with prostaglandin-E1 versus nitric oxide alone.

Pediatric Surgery International
Satoko ShiyanagiAtsuyuki Yamataka

Abstract

Prostaglandin-E1 (PGE1) is used at most centers for treating pulmonary hypertension (PH) in congenital diaphragmatic hernia (CDH) because it has been regarded as effective. The aim of this study was to investigate the role of PGE1 for treating PH in CDH. We reviewed 49 CDH cases with echocardiography-proven PH. PH was treated with PGE1 and nitric oxide (NO) and high frequency oscillatory ventilation (HFOV) from 1997 to 2001 (PG + NO; n = 19) and with NO and HFOV from 2002 to 2007 (NO; n = 30). Subject demographics, severity of PH, and presence of other anomalies were not significantly different between the two groups. In the PG + NO group, 12/19 (63.2%) survived (PG + NO-s) and 7/19 (36.8%) died (PG + NO-d). In the NO group, 21/30 (70.0%) survived (NO-s) and 9/30 (30.0%) died (NO-d). Survival rates were not significantly different. In the NO-s group, spontaneous closure of the ductus arteriosus (DA) was significantly earlier compared with the PG + NO-s group (P < 0.01; 4.0 +/- 0.9 vs. 9.5 +/- 2.2 days after birth). DA diameters were significantly larger in groups that died compared with groups that survived (P < 0.01), and PH persisted in groups that died. In the NO-s group, surgery was possible significantly earlier compared w...Continue Reading

References

Oct 1, 1984·Journal of Pediatric Surgery·J R SiebertJ B Beckwith
Aug 1, 1994·Journal of Pediatric Surgery·N ShahR Simmons
May 17, 2002·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·P BagolanM Orzalesi
Apr 19, 2003·Pediatric Surgery International·Tadaharu OkazakiYasuhiko Tanaka
Mar 16, 2004·Journal of Pediatric Surgery·P BagolanC Giorlandino
Aug 6, 2005·Journal of Pediatric Surgery·Noboru InamuraHisayoshi Kawahara
Sep 14, 2006·Pediatric Surgery International·Manabu OkawadaTakeshi Miyano
Sep 26, 2006·Annals of Surgery·Kevin P LallyUNKNOWN Congenital Diaphragmatic Hernia Study Group

❮ Previous
Next ❯

Citations

Nov 6, 2008·Pediatric Surgery International·Tadaharu OkazakiAtsuyuki Yamataka
Apr 19, 2011·Pediatric Surgery International·Toshiaki TakahashiTadaharu Okazaki
Jun 10, 2010·Indian Journal of Pediatrics·V JainV Bhatnagar
Dec 3, 2014·Seminars in Fetal & Neonatal Medicine·M Pierro, B Thébaud
Dec 25, 2015·The Indian Journal of Surgery·Vasanth H S Kumar
Jan 22, 2009·Acta Paediatrica·Alejandra GaxiolaGenaro Valladolid
Dec 8, 2011·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Edward O'MahonyRicardo Palma-Dias
Dec 18, 2014·World Journal of Pediatrics : WJP·María de Lourdes Lemus-VarelaGuillermo Moisés Zúñiga-González
Jun 10, 2010·Expert Review of Cardiovascular Therapy·Shripada RaoSanjay Patole
Oct 2, 2019·The Cochrane Database of Systematic Reviews·Binoy ShivannaMohan Pammi
May 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Craig R LeeDarryl C Zeldin
Mar 24, 2017·Maternal Health, Neonatology and Perinatology·Praveen Kumar ChandrasekharanSatyan Lakshminrusimha
Jan 1, 2015·Maternal Health, Neonatology and Perinatology·Vinay SharmaSatyan Lakshminrusimha
Apr 14, 2021·Pediatrics International : Official Journal of the Japan Pediatric Society·Miharu ItoUNKNOWN Japanese Congenital Diaphragmatic Hernia Study Group
Jun 7, 2021·European Journal of Pediatrics·Feriel FortasDaniele De Luca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.