Management of radiation-induced severe anophthalmic socket contracture in patients with uveal melanoma.

Ophthalmic Plastic and Reconstructive Surgery
Qasiem J NasserBita Esmaeli

Abstract

High-dose radiotherapy can cause contracture of the anophthalmic socket, but the incidence of this complication in patients with enucleation for uveal melanoma has not been reported previously. The authors reviewed the surgical management and outcomes in terms of successful prosthesis wear in patients with severe contracture of the anophthalmic socket treated with high-dose radiotherapy for high-risk uveal melanoma, and they estimated the relative risk of this complication. The medical records of all consecutive patients enrolled in a prospective uveal-melanoma tissue-banking protocol at the authors' institution who underwent enucleation between January 2003 and December 2010 were reviewed. Patients who underwent adjuvant radiotherapy of the enucleated socket were further studied. Of the 68 patients enrolled in the prospective tissue-banking protocol, 12 had high-risk histologic features (e.g., extrascleral spread or vortex vein invasion) and were treated with 60 Gy of external beam radiotherapy after enucleation. Five of these patients (41.7%) experienced severe socket contracture precluding prosthesis wear. The median time to onset of contracture following completion of radiotherapy was 20 months. Three patients underwent sur...Continue Reading

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Citations

Mar 7, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yi Hsuan Wei, Shu Lang Liao
Aug 21, 2015·Acta Ophthalmologica·Karin C Sundelin, Eva M E Dafgård Kopp
May 10, 2018·The Journal of Craniofacial Surgery·Sultan AlHassanSilvana Artioli Schellini
Feb 7, 2018·Orbit·Andre Grixti, Raman Malhotra
Jun 1, 2014·Current Opinion in Ophthalmology·Elin BohmanEva Dafgård Kopp
Jul 10, 2014·The Journal of Craniofacial Surgery·Chang Yeom KimJin Sook Yoon
Mar 9, 2018·Ophthalmic Plastic and Reconstructive Surgery·Maayke M P KuijtenDyonne T Hartong
Oct 4, 2020·Ophthalmic Plastic and Reconstructive Surgery·Kelsey A RoelofsBertil Damato
Aug 17, 2021·Clinical Ophthalmology·Francesco M Quaranta-LeoniMatteo Di Marino

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