Management of refractory complex partial seizures: current state of the art.

Neuropsychiatric Disease and Treatment
David M Treiman

Abstract

Diagnosis of complex partial epilepsy is based on the clinical history, and laboratory tests, including EEG and neuroimaging studies, corroborate the diagnosis. The goal of epilepsy management is to make the patient completely seizure-free without drug-induced side effects, even in the patient with refractory complex partial seizures. Frequently this can be accomplished by choice of the optimal antiepileptic drug (AED) or a combination of drugs, the use of strategies to maximize the effectiveness of drug treatment, or by surgical removal of the seizure focus. Currently there are five "classical" first-line AEDs and 11 new AEDs available in the US and in many other countries for the treatment of localization-related epilepsy. The current state of the evidence is that no AED is clearly superior to other AEDs in the management of refractory complex partial seizures. Therefore the choice of which drug to use in an individual patient has to be based on other considerations, including the potential adverse reactions that may occur in that patient. There are a number of strategies for optimal use of AEDs in the management of refractory complex partial seizures. These include verification of the diagnosis of epilepsy and classification...Continue Reading

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Citations

Oct 14, 2011·Neuromodulation : Journal of the International Neuromodulation Society·David AbejónPaul Verrills
Jan 25, 2011·Journal of Pharmaceutical Sciences·Selma Gutierrez AntonioCarlos De Oliveira Paiva-santos
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Feb 28, 2018·Journal of Managed Care & Specialty Pharmacy·Jesse FishmanImane Wild
Mar 19, 2013·BMC Medical Research Methodology·Arianne M J ElissenHubertus J M Vrijhoef

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Methods Mentioned

BETA
imaging technique
sedation

Software Mentioned

SISCOM

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