Management of relapsed diffuse large B-cell lymphoma.

Current Oncology Reports
Vaishalee P Kenkre, Sonali M Smith

Abstract

Despite more effective front-line regimens, a substantial portion of patients with diffuse large B-cell lymphoma relapse and require further therapy. Several trials have established the efficacy of autologous stem cell transplantation for relapsed diffuse large B-cell lymphomas, but the benefit has been largely restricted to patients with chemosensitive disease and low-risk features at the time of relapse. In an effort to improve outcomes following an autologous transplant, researchers are exploring several avenues, including improvement of salvage regimens, addition of radioimmunotherapy to preparative regimens, and application of posttransplant treatments to eliminate minimal residual disease. Allogeneic stem cell transplantation also appears promising, but there is much to learn about optimal patient selection and timing. This review outlines the current approach to the management of relapsed diffuse large B-cell lymphoma, with an emphasis on newer peritransplant therapies.

References

Oct 21, 1993·The New England Journal of Medicine·O W PressB Porter
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Oct 21, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Y LiuO W Press
Aug 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A ShippB Coiffier
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J W FriedbergA S Freedman
Nov 30, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C H MoskowitzA D Zelenetz
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M VoseUNKNOWN Autologous Blood and Marrow Transplant Registry Lymphoma Working Committee
Jan 25, 2002·The New England Journal of Medicine·Bertrand CoiffierChristian Gisselbrecht
Aug 28, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K SpaepenG Verhoef
Sep 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katharine BransonStephen Mackinnon
Jan 30, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Julie M VoseMary M Horowitz
Jun 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maricer P EscalónIssa F Khouri
Sep 16, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J RodriguezE Conde
Nov 10, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie M VoseJames O Armitage
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Issa F KhouriRichard E Champlin
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P FeugierB Coiffier
Jun 7, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas M HabermannSandra J Horning
Jun 21, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ajay K GopalOliver W Press
Aug 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frédéric BaronBrenda M Sandmaier
Dec 13, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Roberto RodriguezStephen J Forman

❮ Previous
Next ❯

Citations

Nov 30, 2016·Human Gene Therapy Methods·Tangying Lily LuSteven A Feldman
Apr 3, 2013·Nature Reviews. Clinical Oncology·James N Kochenderfer, Steven A Rosenberg
Nov 15, 2008·International Journal of Dermatology·Anne-Moon van Tuyll van SerooskerkenAriënne M W van Marion
Aug 12, 2009·Hematological Oncology·Cristiana BellanLeoncini Lorenzo
Oct 22, 2009·Hematological Oncology·Cristiana BellanLeoncini Lorenzo
Sep 12, 2014·Journal of the Royal Society, Interface·Luz Adriana Nicasio-CollazoEnrique Hernández-Lemus

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.