Management of relative polycythaemia: studies of cerebral blood flow and viscosity

British Journal of Haematology
P R HumphreyT C Pearson

Abstract

Cerebral blood flow has been shown to be reduced in a group of patients with high packed cell volume due to a reduced plasma volume (relative polycythaemia). 500 ml of intravenous Dextran 40 resulted in a significant fall in PCV and whole blood viscosity with a concomitant rise in cerebral blood flow (CBF). This effect, however, lasted less than 24 h. Oral fludrocortisone therapy (0.2 mg daily) resulted in no definite change in either PCV, viscosity or CBF. Venesection brought about a significant fall in PCV and whole blood viscosity with a significant rise in CBF. Of the methods used, venesection was the only practical long-term method of lowering PCV in this group of patients.

References

Jun 7, 1975·Lancet·P S BurgeT A Prankerd
Jul 23, 1977·Lancet·D J ThomasE Zilkha
Oct 27, 1979·Lancet·P R HumphreyE Zilkha
Jul 12, 1979·The New England Journal of Medicine·A V ChobanianD Faxon
Jan 1, 1979·Clinical and Laboratory Haematology·T C Pearson, G Wetherley-Mein
Jul 1, 1978·Stroke; a Journal of Cerebral Circulation·H TohgiM Kameyama
Aug 1, 1978·Scandinavian Journal of Haematology·T C PearsonG Wetherley-Mein
Jan 1, 1979·Journal of the Neurological Sciences·D J ThomasL Symon
Nov 27, 1976·British Medical Journal·T G Feest
May 11, 1975·Stroke; a Journal of Cerebral Circulation·W D ObristW E Wilkinson
Jul 1, 1972·Stroke; a Journal of Cerebral Circulation·W B KannelP McNamara
Jan 1, 1971·Gerontologia Clinica·M D O'Brien
Nov 1, 1980·British Journal of Haematology·P R HumphreyT C Pearson
Sep 1, 1956·A.M.A. Archives of Internal Medicine·J F FAZEKAS, D NELSON
Nov 1, 1962·Acta Medica Scandinavica·E CHIEVITZ, T THIEDE
Sep 1, 1949·Anesthesiology·S S KETY

❮ Previous
Next ❯

Citations

Mar 1, 1987·Journal of General Internal Medicine·F A Lederle
Feb 27, 1982·British Medical Journal·D W MilliganJ A Davies
Jan 13, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A LucewiczA W Welsh
Mar 1, 1982·British Journal of Haematology·D W MilliganJ A Davies
Nov 1, 1980·British Journal of Haematology·P R HumphreyT C Pearson
Jun 1, 1987·Baillière's Clinical Haematology·T C Pearson, M Messinezy
Aug 1, 1990·Stroke; a Journal of Cerebral Circulation·R G Hart, M C Kanter
Feb 7, 1987·British Medical Journal·M Warren
Jan 20, 2006·The Journal of Parasitology·R R Dahlin-LabordeJ K Beetham
Jan 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·P R Humphrey
Dec 18, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryan L HoilandPhilip N Ainslie
Sep 1, 1993·European Journal of Haematology·M Messinezy, T C Pearson
Feb 7, 1987·British Medical Journal·E M Cooke, R R Marples
Mar 26, 2003·Journal of Internal Medicine·Fredrik Celsing
Dec 1, 1991·Blood Reviews·T C Pearson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.