Management of Resistant Trichomoniasis

Current Infectious Disease Reports
Cynthia Alessio, Paul Nyirjesy

Abstract

Trichomonas vaginalis is the most prevalent sexually transmitted parasite in the USA; resistant infection is emerging. New drug therapies and dosing regimens of standard therapies are being studied to treat resistant infection. Diagnosis of trichomoniasis has become more sensitive, specific, and widely available with the advent of nucleic acid amplification tests (NAATs). Women with resistant trichomoniasis should be treated with high-dose regimens of metronidazole or tinidazole. Alternative treatment options have been described, and there has been some success particularly with high-dose tinidazole/intravaginal paromomycin cream combination, intravaginal boric acid, and intravaginal metronidazole/miconazole. Resistant trichomoniasis is a growing public health concern with implications for long-term health consequences. More data are needed to further evaluate mechanisms by which resistance occurs as well as promising therapies for those affected.

References

Oct 21, 1995·Lancet·P NyirjesyT Fekete
Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·W A Poppe
Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D SobelW Brown
Mar 26, 2003·Antimicrobial Agents and Chemotherapy·Andrea L CrowellW Evan Secor
Sep 16, 2003·Sexually Transmitted Diseases·Tatiana T LoboAugusto Simoes-Barbosa
Jul 12, 2005·International Journal of STD & AIDS·L J WatersP D French
Jan 29, 2008·American Journal of Obstetrics and Gynecology·Donna J HelmsKimberly A Workowski
Mar 11, 2010·International Journal of STD & AIDS·S C TayalH Bunce
Sep 17, 2011·Current Infectious Disease Reports·Megan R Miller, Paul Nyirjesy
Sep 22, 2011·Sexually Transmitted Diseases·Paul NyirjesyLaura J Mulcahy
Sep 22, 2011·Sexually Transmitted Diseases·Elizabeth A BossermanKimberly A Workowski
Feb 22, 2012·Archives of Gynecology and Obstetrics·Maria Elisabete A MoraesPacífica P Cavalcanti
Aug 30, 2013·Journal of Clinical Microbiology·Charles P CartwrightJane R Schwebke
Feb 22, 2014·Expert Review of Anti-infective Therapy·Arlene C SeñaMarcia M Hobbs
Aug 6, 2015·BMC Infectious Diseases·Patricia Kissinger
Nov 26, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elissa MeitesKimberly A Workowski
Feb 27, 2016·F1000Research·David Leitsch
Nov 30, 2016·Sexually Transmitted Diseases·Katharine Howe, Patricia J Kissinger
Dec 11, 2017·Sexually Transmitted Infections·Nicola Thorley, Jonathan Ross
Feb 15, 2018·Antimicrobial Agents and Chemotherapy·Arindam P GhoshJane R Schwebke
Mar 5, 2018·Parasitology Research·M O ChaconMaria Aparecida Gomes
Jan 3, 2019·Sexually Transmitted Diseases·Megan Clare Craig-KuhnPatricia Kissinger

❮ Previous
Next ❯

Citations

Dec 17, 2019·Journal of Travel Medicine·Vivian TienMarisa K Holubar
Oct 20, 2020·Parasitology Research·Gonzalo Mena-RejónMaría Elizbeth Alvarez-Sánchez
Dec 29, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Linda J UrbańskiClaudiu T Supuran
Mar 16, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Andrea AngeliClaudiu T Supuran
Apr 26, 2021·International Journal of Pharmaceutics·Gabriela Corrêa CarvalhoMarlus Chorilli
May 12, 2021·ACS Infectious Diseases·Manal J NattoHarry P de Koning
Dec 7, 2021·Antimicrobial Agents and Chemotherapy·Monica M Kangussu-Marcolino, Upinder Singh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Arlene C SeñaMyron S Cohen
Sexually Transmitted Diseases
Kandis Vechelle BackusLaura S Beauchamps
Current Infectious Disease Reports
Paul Nyirjesy
© 2021 Meta ULC. All rights reserved