Management of sellar and parasellar tumors becoming symptomatic during pregnancy: a practical algorithm based on multi-center experience and systematic literature review.

Pituitary
Matteo ZoliDiego Mazzatenta

Abstract

Sellar/parasellar tumors (SPTs) very rarely become symptomatic during pregnancy. No specific guidelines exist for their management, that is extremely challenging as mother and fetus health can be jeopardized. Data of patients with SPTs becoming symptomatic during pregnancy treated at two Italian referral Centers were retrospectively collected. Systematic literature review was also performed. Our series consisted of 6 cases, 3 meningiomas, 1 ACTH-secreting adenoma, 1 pituicytoma and 1 craniopharyngioma. Mean age at presentation was 33.6 ± 6.0 years. Five patients complained of visual disturbances, associated with headache in one case, that occurred between gestation week (GW) 22 and 34. In 5 cases, pregnancy was uneventful with the delivery of a healthy baby between GW 33 and 35, followed by endoscopic surgical tumor exeresis (n = 4) or proton bean therapy (n = 1). Another patient presented with stigmata typical of Cushing's syndrome and rapidly worsening pre-eclampsia, that required pregnancy interruption and adenomectomy. Based on personal and literature cases, a practical algorithm was proposed to help clinicians dealing with these patients. SPTs becoming symptomatic in pregnancy deserve careful monitoring and multidisciplina...Continue Reading

References

Apr 26, 2006·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·A AtmacaT Erbas
Nov 26, 2009·European Journal of Endocrinology·Z KaracaF Kelestimur
Apr 16, 2010·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Joseph G ChackoEdgardo J Angtuaco
Sep 10, 2010·British Journal of Neurosurgery·José Carlos LynchSara Kislanov
Feb 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Shlomo MelmedUNKNOWN Endocrine Society
Mar 16, 2011·Nature Reviews. Endocrinology·Marcello D BronsteinRaquel S Jallad
Jun 11, 2011·Acta neurochirurgica·Erez NossekZvi Ram
Nov 25, 2011·Seminars in Neurology·Sherry Iuliano, Edward R Laws
Sep 15, 2012·Neurologia Medico-chirurgica·Satoshi ShitaraKazuhiko Nozaki
Jul 16, 2013·World Neurosurgery·Samuel MoscoviciSergey Spektor
Mar 19, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Magali VerheeckeUNKNOWN ESGO Task Force ‘Cancer in Pregnancy’
Aug 28, 2014·Case Reports in Neurological Medicine·Cesare ZoiaPaolo Gaetani
Sep 23, 2014·The Pan African Medical Journal·Hakima Chegour, Nawal El Ansari
Jul 19, 2015·Hormones : International Journal of Endocrinology and Metabolism·Yueye HuangShen Qu
Jul 5, 2016·World Neurosurgery·Rei YamaguchiYuhei Yoshimoto
Mar 1, 2013·Obstetric Medicine·Kimberley Lambert, Catherine Williamson
Nov 22, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Ana GalvãoJorge Braga
Mar 1, 2017·Frontiers of Hormone Research·Federica GuaraldiEzio Ghigo
Jun 22, 2017·Journal of Endocrinological Investigation·Z KaracaF Kelestimur
Feb 18, 2018·World Neurosurgery·Blake H PriddyDaniel M Prevedello
Mar 11, 2018·European Journal of Endocrinology·Thierry BrueFrederic Castinetti
Jun 8, 2018·The Pan African Medical Journal·Houda EnnaiferLeila Ben Salem
May 7, 2019·Journal of Gynecology Obstetrics and Human Reproduction·Manel JemelInes Kamoun
May 8, 2019·BMJ Case Reports·Caroline Annette Erika BachmeierAdam Morton
Jul 28, 2019·Endocrinology and Metabolism Clinics of North America·Wenyu Huang, Mark E Molitch
Mar 5, 2020·The New England Journal of Medicine·Shlomo Melmed

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