Management of severe chronic pain with methadone in pediatric patients with sickle cell disease

Pediatric Blood & Cancer
Zachary LeBlancThomas H Howard

Abstract

Vasocclusive pain crises are common among pediatric patients with sickle cell disease (SCD). Some patients with repeated pain crises develop chronic pain. We performed a retrospective cohort study of pediatric patients with SCD with chronic pain treated with methadone. We identified a significant reduction in pain hospitalizations following methadone treatment (0.35 ± 0.19 vs. 0.19 ± 0.17 hospitalizations/month, P = 0.016). In addition, we did not observe overt organ toxicity nor symptoms of opioid withdrawal during methadone wean. We suggest that methadone is safe and has some clinical benefit, which should be proven in prospective randomized trials for pediatric patients with SCD and chronic pain.

References

Jul 4, 1991·The New England Journal of Medicine·O S PlattT R Kinney
Mar 30, 2005·American Journal of Hematology·Brian O PorterWally R Smith
Jan 16, 2008·Annals of Internal Medicine·Wally R SmithSusan D Roseff
Aug 5, 2009·Pediatric Blood & Cancer·Amanda M BrandowJulie A Panepinto
Sep 14, 2011·Hemoglobin·Miriam H FeliuChristopher L Edwards
Apr 30, 2013·European Journal of Haematology·Bharathi UpadhyaMary Ann Knovich
Sep 18, 2015·The Clinical Journal of Pain·Soumitri SilCarlton Dampier
Mar 19, 2016·International Journal of Legal Medicine·Ilkka OjanperäErkki Vuori
Oct 21, 2016·Pediatric Blood & Cancer·Jennifer HorstEvan D Kharasch

❮ Previous
Next ❯

Citations

Jul 25, 2020·Current Pain and Headache Reports·Mariam Salisu OrhurhuVwaire Orhurhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

The American Journal of the Medical Sciences
M L Freedman
Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Pasquale NiscolaPaolo Cianciulli
© 2022 Meta ULC. All rights reserved