Management of severe complications in Behçet's disease with TNF inhibitors

Expert Opinion on Biological Therapy
A C DesboisD Saadoun

Abstract

The efficacy of anti-TNFα agents has been recently evaluated in many studies in Behçet's disease (BD), particularly in ocular and life-threatening manifestations such as neurological and vascular disease. Areas covered: The following article aims to summarize the currently available efficacy and safety data of anti-TNFα agents in BD. Expert opinion: Most studies have shown dramatic and rapid efficacy with anti-TNFα agents on the main BD-associated issues including posterior uveitis, gastro-intestinal and neurological complications as well as major vessel disease. Experts in the field do recommend the use of anti-TNF agents (either infliximab or adalimumab) as a first-line therapy in severe posterior uveitis in BD and now use anti-TNFα treatment in BD-associated life threatening manifestations. However, data is mainly based on retrospective cohorts or open-label prospective studies. Controlled studies (versus conventional immunosuppressants such as azathioprine and cyclophosphamide) are warranted to properly evaluate their efficacy as first line therapeutic in life-threatening manifestations of BD.

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Citations

Feb 13, 2018·Current Opinion in Rheumatology·Fatma Alibaz-OnerHaner Direskeneli
Apr 18, 2018·International Journal of Rheumatic Diseases·Fatma Alibaz-Oner, Haner Direskeneli
Aug 7, 2018·Current Gastroenterology Reports·David B Sachar
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Sep 28, 2018·The Open Rheumatology Journal·Meriam MessediFatma Ayedi
Apr 2, 2020·VASA. Zeitschrift für Gefässkrankheiten·Chen-Hong LinJian-Long Guan
May 26, 2020·Vascular·Demet Yalçın Kehribar, Metin Ozgen

Jul 18, 2020·La Revue de médecine interne·David Saadoun

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