Management of severe hyperinflammation in the COVID-19 era: the role of the rheumatologist.

Rheumatology
Charalampia PapadopoulouPaul Brogan

Abstract

The objectives of this study were (i) to describe the clinical presentation, treatment and outcome of paediatric inflammatory multisystem syndrome temporally related to Sars-CoV-2 (PIMS-TS) in children; (ii) to propose a framework to guide multidisciplinary team (MDT) management; and (iii) to highlight the role of the paediatric rheumatologist in this context. This study involved a retrospective case notes review of patients referred to a single specialist paediatric centre with suspected PIMS-TS, with a focus on clinical presentation, laboratory parameters, treatment, and outcome in the context of an MDT framework. Nineteen children of median age 9.1 years fulfilled the definition of PIMS-TS and were managed within an MDT framework: 5/19 were female; 14/19 were of Black, Asian or minority ethnicity; 9/19 also fulfilled diagnostic criteria for complete or incomplete Kawasaki disease (KD). Severe systemic inflammation, shock, and abdominal pain were ubiquitous. Treatment was stratified within an MDT framework and included CSs in all; i.v. immunoglobulin in all; anakinra in 4/19; infliximab in 1/19; and antiviral (aciclovir) in 4/19. We observed significant diagnostic equipoise using a current definition of PIMS-TS, overlapping w...Continue Reading

References

Jan 19, 2005·The Journal of Infectious Diseases·Frank EsperJeffrey S Kahn
Dec 20, 2005·The Journal of Infectious Diseases·Luan-Yin ChangUNKNOWN Kawasaki Disease Research Group
Jul 5, 2011·The Journal of Pediatrics·George T NicholsonLeo Lopez
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Xavier RodóJosep-Anton Morguí
Jun 25, 2014·Statistics in Medicine·Lisa V HampsonPaul Brogan
Mar 31, 2017·Circulation·Brian W McCrindleUNKNOWN American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Di
Apr 24, 2020·Lancet·Zsuzsanna VargaHolger Moch
May 11, 2020·Lancet·Shelley RiphagenParaskevi Theocharis
Jun 20, 2020·The European Respiratory Journal·Alice HuertasMarc Humbert

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