Management of severe sepsis and septic shock

Current Opinion in Critical Care
Curtis N SesslerKimberly L Varney

Abstract

Severe sepsis and septic shock are common and deadly conditions for which the epidemiology, pathogenesis, and management continue to evolve. Recent publications (2003 and early 2004) have been systematically reviewed for important new original research and scholarly reviews, with an emphasis on clinical advances in adults. Important new epidemiologic studies establish the increasing frequency (nearly 9% per year) and falling mortality rates associated with sepsis. Sepsis definitions were reviewed by a group of experts, and the principal features of the 1991 consensus conference definitions were supported, with a new framework for evaluation of sepsis proposed. New research and thoughtful reviews continue to elucidate the pathogenesis of sepsis, with emphasis on innate immunity and time-based changes in immune status, varying from hyperreactive immunity and inflammation to immune depression with enhanced risk for nosocomial infections. A comprehensive evidence-based approach to the management of severe sepsis is presented in an important document developed by representatives from many critical care and infectious disease societies. Management includes early targeted resuscitation, broad empiric antibiotic coverage and source con...Continue Reading

References

Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·F MichardJ L Teboul
Mar 10, 2001·The New England Journal of Medicine·G R BernardUNKNOWN Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Jul 5, 2001·Current Opinion in Critical Care·S R Gunn, M R Pinsky
Jan 17, 2002·The New England Journal of Medicine·E RiversUNKNOWN Early Goal-Directed Therapy Collaborative Group
May 25, 2002·The International Journal of Artificial Organs·F ClementeG Tosti
Aug 7, 2002·Critical Care Medicine·Jack W Kern, William C Shoemaker
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Djillali AnnaneEric Bellissant
Nov 12, 2002·American Journal of Respiratory and Critical Care Medicine·Didier KehHerwig Gerlach
Jan 10, 2003·The New England Journal of Medicine·Richard S Hotchkiss, Irene E Karl
Jan 25, 2003·Critical Care Medicine·Derek C AngusUNKNOWN PROWESS Investigators
Jan 25, 2003·Critical Care Medicine·E Wesley ElyUNKNOWN PROWESS Investigators
Jan 25, 2003·Critical Care Medicine·Paul E Marik, Gary P Zaloga
Feb 1, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·David W BatesUNKNOWN AMCC Sepsis Syndrome Working Group. Academic Medical Center Consortium
Feb 1, 2003·BMJ : British Medical Journal·Pierre-Yves Bochud, Thierry Calandra
Feb 11, 2003·Critical Care Medicine·Timothy E AlbertsonUNKNOWN MAB-T88 Sepsis Study Group
Feb 21, 2003·The New England Journal of Medicine·Mark S Cooper, Paul M Stewart
Mar 6, 2003·Critical Care : the Official Journal of the Critical Care Forum·Canan BalcIBünyamin Kaptanoglu
Mar 11, 2003·Critical Care Medicine·Paul E Marik, Aleksandr Bankov
Mar 11, 2003·Critical Care Medicine·Jean-Louis VincentUNKNOWN Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group
Mar 11, 2003·Critical Care Medicine·R Phillip Dellinger
Mar 27, 2003·Current Opinion in Critical Care·Lucas Liaudet, Mauro Oddo
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Apr 30, 2003·Journal of Clinical Anesthesia·Gregor Theilmeier, Michael Booke
May 2, 2003·Critical Care : the Official Journal of the Critical Care Forum·Ramesh VenkataramanJohn A Kellum
May 2, 2003·Critical Care : the Official Journal of the Critical Care Forum·Gordon R BernardJean-Louis Vincent
May 2, 2003·Nature Medicine·Niels C RiedemannPeter A Ward
May 13, 2003·Chest·Curtis N Sessler
Jun 10, 2003·Critical Care : the Official Journal of the Critical Care Forum·D Tony YuUNKNOWN Academic Medical Center Consortium Sepsis Project Working Group

❮ Previous
Next ❯

Citations

Dec 21, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Daniela S KempeFlorian Lang
Sep 22, 2010·Pflügers Archiv : European journal of physiology·Michael FöllerStephan M Huber
Dec 14, 2006·Critical Care : the Official Journal of the Critical Care Forum·Sergio L Zanotti Cavazzoni, R Phillip Dellinger
Aug 1, 2010·Toxins·Chiou-Feng LinMing-Yuan Hong
Mar 18, 2008·Journal of Neuroimmunology·Sammy BedouiStephan von Hörsten
Apr 14, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·A MauriceY Mallédant
Apr 2, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chang-Hee KangGi-Young Kim
Mar 1, 2005·Current Opinion in Infectious Diseases·Grant W Waterer
May 10, 2013·The Journal of Biological Chemistry·Ling GuoXiang-An Li
Nov 12, 2015·Frontiers in Pharmacology·Emily E MorinXiang-An Li
Feb 14, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asada LeelahavanichkulThomas L Eggerman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.