Management of severe strongyloidiasis attended at reference centers in Spain

PLoS Neglected Tropical Diseases
Angela Martinez-PerezSoil-Transmitted Helminths’ Study Group of the Spanish Society of Tropical Medicine and International Health (SEMTSI)

Abstract

Strongyloides stercoralis is a globally distributed nematode that causes diverse clinical symptoms in humans. Spain, once considered an endemic country, has experienced a recent increase in imported cases. The introduction of serology helps diagnosis and is currently replacing microbiological techniques in some settings, but its sensitivity is variable and can be low in immunocompromised patients. Diagnosis can only be confirmed by identification of larvae. Often, this "gold standard" can only be achieved in severe cases, such as disseminated S.stercoralis infection, or S.stercoralis hyperinfection syndrome, where parasite load is high. In addition, these clinical presentations are not well-defined. Our aim is to describe severe cases of S.stercoralis, their epidemiological profile, and their clinical details. An observational retrospective study of disseminated S.stercoralis infection, or hyperinfection syndrome. Inclusion criteria: aged over 18, with a diagnosis of disseminated S.stercoralis infection, or hyperinfection syndrome, confirmed by visualization of larvae. Patients were identified through revision of clinical records for the period 2000-2015, in collaboration with eight reference centers throughout Spain. From the ...Continue Reading

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Feb 15, 2019·Tropical Medicine and Infectious Disease·Prakash ShresthaGregory M Anstead
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Methods Mentioned

BETA
biopsy
biopsies

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