PMID: 11905672Mar 22, 2002Paper

Management of soft-tissue sarcomas: an overview and update

The Lancet Oncology
S SingerC D Fletcher

Abstract

Soft-tissue sarcomas (STS) are relatively uncommon, especially when considered as individual histological subtypes (of which there are more than 50). Their incidence increases with age, although they are disproportionately common among children. When diagnosed and managed in a non-specialist environment, outcome is generally significantly poorer than if patients are managed by a multidisciplinary team in a tertiary centre of excellence. Prompt referral of patients with clinically suspicious masses is strongly advocated, before any type of intervention is attempted. This brief, opinion-based overview emphasises the team approach and provides a synopsis of the strategies used at our institution for pre-operative assessment and biopsy, surgical management, and the delivery of radiation therapy when appropriate (focusing on limb preservation and optimisation of function). Predictable variations in the natural history of these tumours, based on accurate histological subclassification, merit wider recognition. The role of systemic chemotherapy for soft-tissue sarcoma is still evolving, but at present the main aims are improved local control, disease-free survival, and quality of life. There are overall survival benefits for specific ...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·K KarasekR Rosier
Nov 1, 1991·International Journal of Radiation Oncology, Biology, Physics·S F StinsonE J Glatstein
Mar 1, 1991·Archives of Surgery·R G BevilacquaM F Brennan
Jul 1, 1991·Annals of Surgery·F K Storm, D M Mahvi
Oct 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M J ZelefskyM F Brennan
Oct 1, 1995·Journal of Biomechanics·G Wu, P R Cavanagh
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·P TontonozB M Spiegelman
Feb 4, 1998·The British Journal of Surgery·R ClasbyC D Fletcher
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R S BenjaminQ G van Hoesel
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·G D DemetriS Singer
Feb 9, 2000·European Radiology·A M De SchepperJ Somville
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·K M AlektiarL B Harrison
Apr 14, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C S TrovikA Wallöe
Jul 13, 2000·International Journal of Radiation Oncology, Biology, Physics·K M AlektiarM F Brennan

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Citations

Nov 30, 2006·Langenbeck's Archives of Surgery·Moritz N WenteMarkus W Büchler
Sep 28, 2007·Investigational New Drugs·Paolo Andrea ZucaliArmando Santoro
Jun 18, 2011·Endocrine Pathology·Branavan ManoranjanMichael D Cusimano
Aug 17, 2010·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ángel Montero Luis
Jun 12, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F BrounsI De Wever
May 26, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F GrossoP G Casali
Jul 23, 2003·Current Opinion in Oncology·Stephen R Grobmyer, Murray F Brennan
Dec 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert J CanterSamuel Singer
Apr 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Suizhao WangDina Lev
Apr 20, 2005·World Journal of Surgical Oncology·Marcus LehnhardtHeinz H Homann
Mar 2, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Cheryl M CoffinLouis P Dehner
Nov 12, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·M InnocentiC Baldrighi
Apr 15, 2006·Annals of Surgical Oncology·Katja M J ThijssensHarald J Hoekstra
Jul 23, 2014·Musculoskeletal Surgery·H J MankinD C Harmon
Sep 15, 2012·World Journal of Surgical Oncology·Irfan QadirMuhammad Sharoz Rabbani
May 12, 2009·World Journal of Surgery·Anja LachenmayerMatthias Peiper
Jun 5, 2008·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M LehnhardtH U Steinau
Jan 22, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·F Lordick
Jun 23, 2011·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·M LehnhardtH U Steinau
Mar 6, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D FuksC Marchal
Apr 21, 2006·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·C ChewP J O'Dwyer
Dec 6, 2007·Surgical Neurology·Jun ZhongLiang Wan
May 20, 2015·Scientific Reports·Devyani SamantarraiBibekanand Mallick
Sep 16, 2014·Journal of Surgical Oncology·Gadini O DeliscaGinger E Holt
Nov 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Alberto BossiBianca Vanstraelen
Jun 2, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F GrossoP G Casali
Aug 20, 2011·Drug and Chemical Toxicology·Lars SteinstraesserFrank Jacobsen
Jul 22, 2015·Aesthetic Plastic Surgery·Pierfrancesco CadenelliAndrea Marchesi
Jul 15, 2015·The Journal of Surgical Research·Noah K YuenRobert J Canter
Jun 5, 2015·Frontiers in Surgery·Andrew LindfordSwee T Tan
Apr 1, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ruiz-Soto RodrigoLe Cesne Axel
Sep 21, 2002·Cancer Cell·Crystal L MackallLee J Helman
Jan 1, 2010·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Vincenzo RavoPaolo Muto

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