Management of squamous cell and basal cell carcinomas of the head and neck with perineural invasion

The Australasian Journal of Dermatology
Aakriti GuptaShyamala Huilgol

Abstract

Perineural invasion (PNI) occurring in non-melanoma skin cancers (NMSC) is associated with an increased risk of locoregional recurrence and reduced disease-free survival. This necessitates early and accurate diagnosis, appropriate risk-stratification and a clear management strategy. The diagnosis of PNI is based on careful clinical assessment, imaging and histopathology. Surgery, preferably with margin control, and definitive or adjuvant radiotherapy (ART) are established treatment strategies for PNI. Clinical uncertainty remains over the role of ART in incidental PNI. This review synthesises current literature to ascertain which clinicopathological features impart a higher risk to individuals with PNI in NMSC, in order to provide treatment algorithms, including the identification of patient subsets that are most likely to benefit from ART. This includes those with extratumoural PNI, involvement of larger-calibre nerves, tumour invasion beyond dermis, recurrent tumour or diffuse intratumoural spread. Patients with clinical PNI may be optimally managed by a multidisciplinary head and neck cancer service that is best placed to offer skull base surgery and intensity-modulated radiation therapy (IMRT). The management options presen...Continue Reading

References

Mar 17, 1999·International Journal of Radiation Oncology, Biology, Physics·M W McCordF P Flowers
Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·M W McCordR R Million
May 17, 2000·The Australasian Journal of Dermatology·M J Veness
Mar 10, 2001·International Journal of Radiation Oncology, Biology, Physics·L S WilliamsW M Mendenhall
Jul 10, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·A M FeaselB R Nelson
Jan 5, 2002·Head & Neck·William M MendenhallNancy Price Mendenhall
Dec 4, 2003·Head & Neck·Allie Garcia-SerraAnthony A Mancuso
Apr 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Thomas StaskoUNKNOWN European Skin Care in Organ Transplant Patients Network
Jul 16, 2005·Journal of the American Academy of Dermatology·Igal LeibovitchRobert Paver
Aug 23, 2005·Journal of the American Academy of Dermatology·Igal LeibovitchRobert Paver
Sep 17, 2005·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ashraf M HassaneinFranklin P Flowers
Dec 14, 2005·Current Treatment Options in Oncology·Zoran RumboldtSusan Ackermann
Feb 1, 2006·The British Journal of Dermatology·C C OtleyUNKNOWN REDUCTION OF IMMUNOSUPPRESSION TASK FORCE OF THE INTERNATIONAL TRANSPLANT SKIN CANCER COLLABORATIVE and THE SKIN CARE IN ORG
Feb 10, 2006·Journal of Cutaneous Pathology·David S CassarinoRonald J Barr
Apr 25, 2006·Journal of Cutaneous Pathology·David S CassarinoRonald J Barr
Feb 7, 2007·American Journal of Clinical Oncology·William M MendenhallNancy P Mendenhall
Mar 17, 2007·Clinical & Experimental Ophthalmology·Vanessa LimawararutDinesh Selva
Jun 2, 2007·Journal of Biomedicine & Biotechnology·Michael J Veness
Jul 28, 2007·Nature Clinical Practice. Oncology·Julie A NevilleDavid J Leffell
Feb 28, 2008·Topics in Magnetic Resonance Imaging : TMRI·Stefan Franz NemecChristian Czerny
Oct 22, 2008·International Journal of Radiation Oncology, Biology, Physics·Iris GluckAvraham Eisbruch
Nov 21, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·David E GeistGary S Rogers
Feb 13, 2009·Journal of Cutaneous Pathology·Martin DunnScott M Acker
Feb 14, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Martin DunnTrevor W Beer
Jun 2, 2009·Cancer·Catherine LiebigDaniel Albo
Aug 18, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ross B ReuleRonald G Wheeland
Aug 19, 2009·The Laryngoscope·William M MendenhallNancy P Mendenhall
Nov 6, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Amy S RossChrysalyne D Schmults
Dec 18, 2009·American Journal of Otolaryngology·Renee PennClaudia Kirsch
Sep 3, 2010·Transplantation·David G LottRobert R Lorenz
Sep 28, 2010·Journal of the National Comprehensive Cancer Network : JNCCN·Stanley J MillerJohn A Zic
Nov 6, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Melissa Pugliano-Mauro, Glenn Goldman
Nov 17, 2010·Archives of Dermatology·Anokhi Jambusaria-PahlajaniChrysalyne D Schmults
Nov 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Charles LinGraeme Dickie
Mar 23, 2011·Dermatologic Clinics·Navid Bouzari, Suzanne Olbricht
May 11, 2011·Expert Review of Anticancer Therapy·Venura SamarasingheJohn T Lear
Jun 15, 2011·Oral Oncology·UNKNOWN Expert Panel on Radiation Oncology-Head and NeckJonathan J Beitler
Dec 22, 2011·American Journal of Otolaryngology·Christopher J BalamuckiWilliam M Mendenhall
Mar 1, 2012·Expert Review of Anticancer Therapy·Meredith JohnstonJohn Kim
Mar 20, 2012·Oral Oncology·William M MendenhallJuan P Rodrigo
Jun 8, 2012·The New England Journal of Medicine·Aleksandar SekulicAxel Hauschild

❮ Previous
Next ❯

Citations

Jul 15, 2017·The Australasian Journal of Dermatology·Lauren YoungZoran Gaspar
Jan 20, 2018·The Australasian Journal of Dermatology·Edmund WeeEmma L Hiscutt
Feb 15, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Berenice M LangStephan Grabbe
Feb 15, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Berenice M LangStephan Grabbe
Nov 26, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Mary-Katharine CollinsMelissa Pugliano-Mauro
Apr 15, 2020·The Australasian Journal of Dermatology·Agnieszka AdamsDavid C Whiteman
Mar 14, 2018·International Journal of Oncology·Mei ZhangYa-Ling Tang
Nov 20, 2016·Archives of Dermatological Research·Katrin SchweinzerHans-Martin Häfner
Apr 2, 2019·The Australasian Journal of Dermatology·Kieran B Garbutcheon-Singh, Michael J Veness
Feb 6, 2020·The Australasian Journal of Dermatology·Agnieszka AdamsDavid C Whiteman
Oct 10, 2020·Current Treatment Options in Oncology·Francesca CaparrottiThomas Zilli
Sep 15, 2020·Neurosurgery Clinics of North America·Saber Tadros, Abhik Ray-Chaudhury
Jun 10, 2021·American Journal of Clinical Dermatology·Albert E ZhouAmor Khachemoune
Nov 24, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Evi M MorandiDolores Wolfram
Nov 24, 2021·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Evi M MorandiDolores Wolfram

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.