Management of the focal nodular hyperplasia of the liver: evaluation of the surgical treatment comparing with observation only

American Journal of Surgery
Aristotelis PerrakisSüleyman Yedibela

Abstract

Long-term results of both surgery and observation for patients with focal nodular hyperplasia (FNH) in a large single-center experience do not exist. Accordingly, the aim of this study was to compare long-term outcomes in patients with FNH who underwent either elective hepatectomy or observation alone. A retrospective single-institution analysis of 185 patients with FNH, treated from 1990 to 2009, was performed. Seventy-eight patients underwent elective hepatectomy and 107 patients observation alone, with a median follow-up period of 113 months. There was no perioperative mortality. Postoperative complications were recorded in 12 patients, and 92% of patients reported symptomatic reductions. Among observation patients, 9 (13%) developed additional symptoms; tumor enlargement was seen in 3 patients (4%). Elective liver resection for FNH is a safe procedure at high-volume centers. This single-center experience showed that 13% of observed patients had protracted symptoms. This justifies the therapeutic algorithm that elective surgery should be considered in symptomatic patients or in those with marked enlargement.

References

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Citations

Jul 18, 2015·Clinical Journal of Gastroenterology·Kazuto TajiriToshiro Sugiyama
Jun 29, 2013·Updates in Surgery·Agustin CristianoEduardo de Santibañes
Sep 5, 2013·Journal of Vascular and Interventional Radiology : JVIR·Jeff BirnTodd Getzen
Mar 15, 2013·Gastroenterology·Jean-Charles NaultJessica Zucman-Rossi
Mar 3, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Manju D ChandrasegaramChristopher S Worthley
Nov 1, 2013·Journal of Medical Imaging and Radiation Oncology·Tom SutherlandKelvin Yap
Apr 18, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL)
Jan 7, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Georgios Antonios MargonisTimothy M Pawlik
Oct 27, 2015·European Journal of Medical Research·Hans Michael HauMichael Bartels
Jun 20, 2014·Acta chirurgica Belgica·D DimitroulisG Kouraklis
May 28, 2020·Korean journal of family medicine·Fadi Abu BakerAmir Mari
Jan 19, 2021·ACG Case Reports Journal·Ashraf A AshhabWalid S Ayoub
Aug 8, 2021·BMJ Open Gastroenterology·Martijn P D HaringVincent E de Meijer

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