Management of the hormonal syndrome of neuroendocrine tumors

Archives of Medical Science : AMS
Paweł GutMarek Ruchała

Abstract

Gastroenteropancreatic neuroendocrine tumors (GEP/NET) are unusual and rare neoplasms that present many clinical challenges. They characteristically synthesize store and secrete a variety of peptides and neuroamines which can lead to the development of distinct clinical syndrome, however many are clinically silent until late presentation with mass effects. Management strategies include surgery cure and cytoreduction with the use of somatostatin analogues. Somatostatin have a broad range of biological actions that include inhibition of exocrine and endocrine secretions, gut motility, cell proliferation, cell survival and angiogenesis. Five somatostatin receptors (SSTR1-SSTR5) have been cloned and characterized. Somatostatin analogues include octreotide and lanreotide are effective medical tools in the treatment and present selectivity for SSTR2 and SSTR5. During treatment is seen disapperance of flushing, normalization of bowel movements and reduction of serotonin and 5-hydroxyindole acetic acid (5-HIAA) secretion. Telotristat represents a novel approach by specifically inhibiting serotonin synthesis and as such, is a promising potential new treatment for patients with carcinoid syndrome. To pancreatic functionig neuroendocrine ...Continue Reading

Citations

Oct 12, 2017·Critical Reviews in Food Science and Nutrition·Marco GalloUNKNOWN NIKE Group
Feb 9, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·R FeldmannA Steiner
Feb 22, 2018·Reviews in Endocrine & Metabolic Disorders·Xi-Feng JinChristoph J Auernhammer
Sep 3, 2020·World Journal of Gastroenterology : WJG·Mohid S KhanEnrique Grande
Jan 21, 2019·BMJ Case Reports·Marius VögelinThomas Fehr
Jul 16, 2020·Journal of Clinical Medicine·Maria Isabel Del Olmo-GarcíaJuan-Francisco Merino-Torres
May 23, 2019·World Journal of Gastroenterology : WJG·Thomas LangbeinRichard P Baum

❮ Previous
Next ❯

Methods Mentioned

BETA
irradiate

Software Mentioned

TELESTAR

Related Concepts

Related Feeds

Carcinoma, Islet Cell (Keystone)

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arise in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on islet cell carcinoma in this feed.

Carcinoma, Islet Cell

Islet Cell Carcinoma or Pancreatic Neuroendocrine Tumours arises in the hormone producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Carcinoma here.

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Related Papers

World Journal of Gastroenterology : WJG
Sara MassironiDario Conte
Endocrinology and Metabolism Clinics of North America
Vay Liang W GoLeigh Anne Kamerman Burns
Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer
H C FehmannR Arnold
The Lancet Oncology
Irvin M ModlinAnders Sundin
© 2022 Meta ULC. All rights reserved