Jun 1, 1989

Management of tubal pregnancy with methotrexate

British Journal of Obstetrics and Gynaecology
H ZakutD Bernstein


Ten women with tubal ectopic pregnancy were treated by the injection of methotrexate into the gestational sac under direct laparoscopic vision followed by a course of intramuscular therapy including folinic acid rescue. One course of treatment induced resolution of the extrauterine pregnancy in eight women. Complete resolution (beta-hCG less than 10 miu/ml) was achieved within 6-47 days (mean 14.5 days). Serum beta-hCG levels started to decline 3.4 days from the beginning of therapy. Length of hospital stay was 5-11 days (mean 6.4 days). Treatment failed in two patients. One woman had a laparoscopic tubal clip sterilization concomitantly with methotrexate treatment. Tubal patency was demonstrated in all the other seven women (100%) tested subsequently. There is a need to establish criteria for patient selection before methotrexate becomes a routine treatment for tubal pregnancy.

  • References8
  • Citations11


  • References8
  • Citations11


Mentioned in this Paper

Chorionic Gonadotropin, beta Subunit, Human
Fallopian Tube Diseases
Pregnancy, Tubal
Peptide Fragments
Leucovorin, Calcium (1:1) Salt, Pentahydrate
Methotrexate, (DL)-Isomer
Surgical Procedures, Laparoscopic

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