Management of Viral Hepatitis in Solid Organ Transplant Recipients

Infectious Disease Clinics of North America
Elizabeth Buganza-Torio, Karen Doucette

Abstract

With potent nucleos(t)ide analogue (NA) therapy, hepatitis B virus (HBV) is now an uncommon indication for liver transplant (LT) in North America. NA therapy, with or without hepatitis B immunoglobulin, results in low recurrence rates and excellent outcomes after LT. Direct-acting antiviral therapy for hepatitis C virus (HCV), results in cure in most patients, either before or after transplant. There are now descriptions of good clinical outcomes of transplant from HBV and HCV infected donors, as treatments are so effective and well tolerated. Hepatitis E virus in transplantation requires a high suspicion to diagnose and optimal therapy remains incompletely defined.

Citations

Mar 13, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Danae BixlerAnne Moorman

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