Managing bioengineering complexity with AI techniques

Bio Systems
Jacob BealFusun Yaman

Abstract

Our capabilities for systematic design and engineering of biological systems are rapidly increasing. Effectively engineering such systems, however, requires the synthesis of a rapidly expanding and changing complex body of knowledge, protocols, and methodologies. Many of the problems in managing this complexity, however, appear susceptible to being addressed by artificial intelligence (AI) techniques, i.e., methods enabling computers to represent, acquire, and employ knowledge. Such methods can be employed to automate physical and informational "routine" work and thus better allow humans to focus their attention on the deeper scientific and engineering issues. This paper examines the potential impact of AI on the engineering of biological organisms through the lens of a typical organism engineering workflow. We identify a number of key opportunities for significant impact, as well as challenges that must be overcome.

References

Sep 11, 2007·Journal of Molecular Biology·Chu WangDavid Baker
Jul 10, 2008·Nature Biotechnology·Barry CantonDrew Endy
Apr 14, 2009·Nature Methods·Daniel G GibsonHamilton O Smith
Apr 17, 2009·Journal of the Royal Society, Interface·Michael Pedersen, Andrew Phillips
May 12, 2009·Nucleic Acids Research·Michael J CzarJean Peccoud
Mar 26, 2010·Nucleic Acids Research·Douglas DensmoreJ Christopher Anderson
Mar 3, 2011·PloS One·Ernst WeberSylvestre Marillonnet
Mar 15, 2011·PLoS Computational Biology·Mario A Marchisio, Jörg Stelling
Oct 5, 2012·Nature Biotechnology·Chunbo LouChristopher A Voigt
Jan 20, 2012·ACS Synthetic Biology·Nathan J HillsonJay D Keasling
May 9, 2013·ACS Synthetic Biology·Fusun YamanJacob Beal
Jun 1, 2014·ACS Synthetic Biology·Jacob BealRon Weiss

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Citations

Dec 1, 2020·Critical Reviews in Food Science and Nutrition·Prasoon KumarPratyoosh Shukla
Feb 28, 2018·ACS Synthetic Biology·Ellis WhiteheadJörg Stelling

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