Managing cancer-related anorexia/cachexia

Drugs
Giovanni MantovaniClelia Madeddu

Abstract

Cancer-related anorexia/cachexia (CAC) is a complex phenomenon in which metabolic abnormalities, proinflammatory cytokines produced by the host immune system, circulating tumour-derived catabolic factors, decreased food intake, and probably additional unknown factors, all play different roles. This review examines the mechanisms of CAC and its management. All the potential modalities of intervention from nutritional to pharmacological approaches are included with a clear distinction between unproven, investigational and well established treatments. Among the latter, the progestogens are currently considered the most effective and safest drugs for the management of CAC. Agents currently under investigation for CAC include thalidomide, pentoxifylline and melatonin, which most probably act on cytokine release, and clenbuterol, which acts on muscle mass and to antagonise protein wasting. Our personal experience with the synthetic progestogens megestrol and medroxyprogesterone supports their use as first-line agents. In addition, our work on the potential role of antioxidant agents in counteracting the oxidative stress, which appears to be involved in CAC, shows them to be promising agents when used in combination chemotherapy regim...Continue Reading

References

Nov 12, 1977·British Medical Journal·H B StonerD W Yates
Aug 1, 1977·The American Journal of Clinical Nutrition·C L Long
Nov 1, 1992·JPEN. Journal of Parenteral and Enteral Nutrition·L L MoldawerS F Lowry
Oct 1, 1992·American Journal of Clinical Oncology·J FeliuJ M Montero
Apr 16, 1992·The New England Journal of Medicine·G B VogelsangJ R Wingard
May 1, 1992·The Journal of Clinical Investigation·G StrassmannC O Jacob
Mar 1, 1992·Cancer·N S TchekmedyianJ Aisner
Jul 4, 1990·Journal of the National Cancer Institute·C L LoprinziL H Geeraerts
Nov 1, 1990·British Journal of Cancer·S A BeckM J Tisdale
Dec 19, 1990·Journal of the National Cancer Institute·S A BeckM J Tisdale
Dec 23, 1989·Lancet·P ZabelU F Schade
Jan 1, 1985·Annual Review of Physiology·E R FroeschJ Zapf
Jan 1, 1987·Metabolism: Clinical and Experimental·C M DreslerM F Brennan
Dec 1, 1987·The American Journal of Physiology·L L MoldawerK G Lundholm
Oct 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H VlassaraA Cerami
Jan 19, 1974·Lancet·D W WilmoreR H Unger
Oct 1, 1974·Annals of Surgery·D W WilmoreB A Pruitt
Oct 1, 1984·Arthritis and Rheumatism·O Gutiérrez-Rodríguez
Jan 7, 1984·British Medical Journal·J C WilloxM Drennan
Feb 1, 1983·American Journal of Surgery·K ShivshankerT P Haynie
Feb 1, 1983·Archives of Surgery·S RosenblattB Lindberg
Jan 1, 1981·Journal of Chronic Diseases·W O SpitzerB R Catchlove
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoJ Folkman
Nov 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R M GoldbergT G Shanahan
Aug 1, 1995·Free Radical Biology & Medicine·L PackerH J Tritschler
Feb 1, 1995·Journal of Pain and Symptom Management·J E BealK V Shepard
Oct 1, 1994·Journal of Pain and Symptom Management·S Watanabe, E Bruera

❮ Previous
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Citations

Oct 6, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Giovanni MantovaniFilomena Panzone
Jul 6, 2004·Cancer Chemotherapy and Pharmacology·J P CataP M Dougherty
Jul 5, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Carlos CampsRafael Sirera
Aug 19, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Giovanni Mantovani, Clelia Madeddu
Dec 31, 2003·Current Treatment Options in Oncology·Leno ThomasMartin J Edelman
Apr 9, 2002·Current Oncology Reports·Mellar P Davis
Jun 19, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Paula RavascoMaria Ermelinda Camilo
Jul 30, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·David Hamerman
Apr 16, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Luiz Carlos Carvalho NavegantesIsis do Carmo Kettelhut
Jun 14, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Akio Inui, Michael M Meguid
Jun 12, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Eduardo J B RamosMichael M Meguid
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Carolina G GoncalvesMichael M Meguid
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Sususmu SuzukiMichael M Meguid
Jun 17, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Elamin M ElaminEnrico Camporesi
Jun 13, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Nyaladzi BalogunAnne Lanceley
Feb 16, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Brian C Clark, Todd M Manini
Mar 19, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Christopher C CossJames T Dalton
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Simona Perboni, Akio Inui
Aug 29, 2012·International Journal of Dentistry·Fanny López-MartínezRicardo Martínez Pedraza
Aug 27, 2013·Drug Design, Development and Therapy·Giovanni MantovaniAntonio Macciò
Jun 30, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Robert A Femia, Richert E Goyette
Apr 17, 2009·Medicinski pregled·Tatjana SarcevDorde Povazan
Nov 30, 2006·Indian Journal of Medical Sciences·T RavindraY R Ahuja
Jan 11, 2011·Indian Journal of Palliative Care·Em Tazi, H Errihani
May 28, 2014·Chemical Senses·Marie FischerNorbert Joachim Thuerauf
Mar 21, 2013·Journal of Gastroenterology·Hajime SuzukiAkio Inui
Aug 8, 2008·Current Opinion in Supportive and Palliative Care·Autumn L Fletcher, Daniel L Marks
May 19, 2009·Expert Opinion on Pharmacotherapy·Clelia MadedduGiovanni Mantovani
May 7, 2014·Advances in Medical Sciences·Ilaria RongaGeneroso Uomo
Oct 23, 2010·Journal of Pain and Symptom Management·Eric E PrommerAndrew Wilcock
Mar 3, 2009·Cancer Treatment Reviews·Camillo Porta, Cezary Szczylik
Dec 9, 2008·Pharmacology & Therapeutics·Stephan von HaehlingStefan D Anker
Jun 3, 2008·The Nursing Clinics of North America·Georgia M Decker
Nov 8, 2015·International Journal of Cardiology·Goran LoncarMitja Lainscak
Jan 20, 2004·Journal of the American Geriatrics Society·Brooke N BosleyEvelyn Granieri
Jul 16, 2008·Journal of Cellular and Molecular Medicine·Antonio MacciòGiovanni Mantovani
Mar 28, 2012·Journal of Cachexia, Sarcopenia and Muscle·Mary A Honors, Kimberly P Kinzig
Mar 22, 2014·Journal of Cellular Physiology·Marine GilabertJuan Iovanna
Jul 19, 2003·Journal of Chemotherapy·G LelliD Scapoli
Jun 7, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vikas DuttAshwani Mittal
Mar 19, 2014·Head & Neck·Marion E CouchHirak Der-Torossian
Jun 27, 2015·The Journal of Endocrinology·Maria Carolina S MendesJosé B C Carvalheira

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