Managing depressive symptoms in people with mild cognitive impairment and mild dementia with a multicomponent psychotherapy intervention: a randomized controlled trial.

International Psychogeriatrics
Johanne B TongaIngun D Ulstein

Abstract

To evaluate the feasibility and effectiveness of the CORDIAL program, a psychosocial intervention consisting of cognitive behavioral therapy (CBT), cognitive rehabilitation, and reminiscence to manage depressive symptoms for people with mild cognitive impairment (MCI) or dementia. We conducted a randomized controlled trial, based on a two-group (intervention and control), pre-/post-intervention design. Participants were recruited from five different old age psychiatry and memory clinics at outpatients' hospitals. Hundred and ninety-eight people with MCI or early-stage dementia were included. The intervention group (n = 100) received 11 individual weekly sessions of the CORDIAL program. This intervention includes elements from CBT, cognitive rehabilitation, and reminiscence therapy. The control group (n = 98) received treatment-as-usual. We assessed Montgomery-Åsberg Depression Rating Scale (MADRS) (main outcome), Neuropsychiatric Inventory Questionnaire, and Quality of Life in Alzheimer's disease (secondary outcomes) over the course of 4 months and at a 10-month follow-up visit. A linear mixed model demonstrated that the depressive symptoms assessed by MADRS were significantly more reduced in the intervention groups as compared...Continue Reading

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Citations

Mar 31, 2021·International Psychogeriatrics·Bob Woods

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