Managing odds in stem cells: insights into the role of mitochondrial antioxidant enzyme MnSOD

Free Radical Research
Preethi Sheshadri, Anujith Kumar

Abstract

Reactive oxygen species (ROS) have been poised at a straddled state of being beneficiary as well detrimental depending on its threshold levels. Maintaining the homeostasis of ROS is imperative for normal cellular physiology, wherein physiological concentrations of ROS are involved in cell signaling and elevated ROS contribute to the development of various diseases. Superoxide dismutases (SODs), enzymes involved in dismutation of superoxide anion to hydrogen peroxide, arrive as a first line of defense when there is perturbation in the homeostasis of ROS. As mitochondria are the main site of superoxide production, among SODs, mitochondrial manganese SOD (MnSOD) is the primary antioxidant enzyme that protects cells from ROS. Most importantly, knockout of MnSOD leads to postnatal lethality and tissue-specific conditional knockout in brain resulted in death of mice, conclusively portraying the essential role of MnSOD in development. Although MnSOD has been extensively discussed with the purview of tumor biology and aging, understanding the crucial role of MnSOD in stem cell physiology is still at its infant stage. Ever increasing progress in stem cell research has recently unveiled the essential role of MnSOD in self-renewal and dif...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Nov 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A MunimK Kato
Jul 1, 1991·Human Reproduction·M Legge, M H Sellens
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D C DeanS Bourgeois
Oct 1, 1986·Annals of the Rheumatic Diseases·S L MarklundL G Elmqvist
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S L Marklund
Nov 24, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·S L MarklundL Hellner
May 6, 1994·Journal of Molecular Biology·D BordoM Bolognesi
Oct 1, 1993·British Journal of Haematology·J M LiuN S Young
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·J S RosenblumR A Lerner
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·R M LebovitzM M Matzuk
Apr 29, 1998·The Journal of Biological Chemistry·Y S HoR J Hutz
Dec 16, 1998·Journal of Gastroenterology·R IzutaniH Ohyanagi
Apr 2, 1999·Science·M F PittengerD R Marshak
Oct 26, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G F Van LandeghemP M Andersen
Jan 25, 2000·The Journal of Surgical Research·M MalafaM Christophersen
Aug 9, 2001·Antioxidants & Redox Signaling·L W Oberley
Aug 15, 2002·Biochemical and Biophysical Research Communications·Takashi IkegamiTakuji Shirasawa
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Joan Selverstone Valentine, P John Hart
May 6, 2003·The Journal of Nutrition·Esther Casanueva, Fernando E Viteri
Feb 24, 1956·Science·O WARBURG
Oct 17, 2003·The Journal of Physiology·Julio F Turrens
Mar 10, 2004·Cell·Amy J Wagers, Irving L Weissman
Jun 5, 2004·The Journal of Biological Chemistry·Ye-Shih HoDorothy S Ho
Sep 24, 2004·Physiological Reviews·Roland Stocker, John F Keaney

❮ Previous
Next ❯

Citations

Aug 2, 2019·Rejuvenation Research·Tullia MaraldiCristina Angeloni
Oct 1, 2020·Contrast Media & Molecular Imaging·Per JyngeJan O G Karlsson
Mar 28, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Sarah A BreedonKenneth B Storey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.