MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain

Molecular and Cellular Neurosciences
Päivi LindholmMart Saarma

Abstract

The mesencephalic astrocyte-derived neurotrophic factor (MANF) has been described as a survival factor for dopaminergic neurons in vitro, but its expression in mammalian tissues is poorly known. MANF and a homologous protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. Here we used in situ hybridization and immunohistochemistry to characterize MANF expression in developing and adult mouse. MANF expression was widespread in the nervous system and non-neuronal tissues. In the brain, relatively high MANF levels were detected in the cerebral cortex, hippocampus and cerebellar Purkinje cells. After status epilepticus, Manf mRNA expression was transiently increased in the dentate granule cell layer of hippocampus, thalamic reticular nucleus and in several cortical areas. In contrast, following global forebrain ischemia changes in Manf expression were widespread in the hippocampal formation and more restricted in cerebral cortex. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

References

Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Dec 1, 1993·Experimental Neurology·D G SchaarI B Black
Mar 21, 1996·Nature·D M GashG A Gerhardt
Apr 2, 1999·The European Journal of Neuroscience·Z KokaiaM Saarma
Feb 13, 2001·Trends in Neurosciences·D K BinderH E Scharfman
May 4, 2002·Nature Reviews. Neuroscience·Matti S Airaksinen, Mart Saarma
Feb 21, 2003·Current Opinion in Neurobiology·Zaal Kokaia, Olle Lindvall
Jun 10, 2003·Journal of Molecular Neuroscience : MN·Penka PetrovaJohn W Commissiong
Oct 18, 2003·Stroke; a Journal of Cerebral Circulation·Elin GustafssonZaal Kokaia
Aug 10, 2004·Cell and Tissue Research·Kerstin Krieglstein
Jan 16, 2007·Trends in Pharmacological Sciences·Maxim M Bespalov, Mart Saarma
May 18, 2007·Cell Structure and Function·Naomi MizobuchiKazuhiro Nagata
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Wolf-Rüdiger SchäbitzH Georg Kuhn

❮ Previous
Next ❯

Citations

Jul 10, 2010·Biomolecular NMR Assignments·Maarit HellmanPerttu Permi
Nov 5, 2010·The Journal of Biological Chemistry·Maarit HellmanPerttu Permi
Mar 5, 2009·Protein Engineering, Design & Selection : PEDS·Vimal ParkashAdrian Goldman
Nov 3, 2011·PloS One·Yinzhi LaiWilliam S Kisaalita
Mar 4, 2014·PloS One·Haiping WangJia Luo
Mar 13, 2014·Drugs & Aging·Tiago Martins RodriguesMaria José Diógenes
Aug 21, 2015·The International Journal of Neuroscience·Yingchao Su, Feng Li
Jul 7, 2011·FEBS Letters·Kentaro Oh-hashiKazutoshi Kiuchi
Sep 17, 2014·The American Journal of the Medical Sciences·Jiajia WangYuxian Shen
Mar 13, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Daniel Martinez-FongIvan Navarro-Quiroga
Jun 22, 2011·Cytokine & Growth Factor Reviews·Aideen M Sullivan, André Toulouse
Dec 28, 2010·Experimental Neurology·Merja H VoutilainenRaimo K Tuominen
Oct 26, 2010·Journal of Molecular and Cellular Cardiology·Christopher C Glembotski
Jun 15, 2010·Progress in Neurobiology·K L DoubleG M Halliday
Sep 24, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yong-Qiang YuYu-Xian Shen
Oct 3, 2015·Human Immunology·Jun LiuYuxian Shen
Feb 27, 2010·Developmental Neurobiology·Päivi Lindholm, Mart Saarma
May 9, 2015·Functional & Integrative Genomics·Sanaya F BamjiCynthia Corbitt
Jul 16, 2015·Human Gene Therapy·Andrii DomanskyiMikko Airavaara
Apr 29, 2015·Gene Expression Patterns : GEP·Vassilis Stratoulias, Tapio I Heino
Aug 18, 2012·Developmental Biology·Y-C ChenP Panula
Jan 17, 2012·The International Journal of Neuropsychopharmacology·Lennard P NilesYi Pan
Nov 6, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Óscar Cordero-LlanaMaeve A Caldwell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.