Manganese catalyzed auto-oxidation of dopamine to 6-hydroxydopamine in vitro

Chemico-biological Interactions
C D Garner, J P Nachtman

Abstract

Manganese (Mn) is an essential trace element which, upon excessive exposure, produces a neurological syndrome similar to chronic Parkinson's disease in animals and humans. Previous work demonstrated that Mn was more potent than other transition metals in stimulating dopamine (DA) auto-oxidation. In these experiments, DA was incubated under physiological conditions in the presence and absence of Mn for up to 60 min. 6-Hydroxydopamine (6-OHDA) was produced in the presence of Mn, while the incubation mixture without Mn showed no DA oxidation. 6-Hydroxydopamine is a neurotoxicant which exerts its effects by destroying DA nerve terminals in the CNS. Therefore, this work suggests that the Mn catalyzed increase in DA auto-oxidation could be linked mechanistically to the appearance of Mn-induced neurotoxic effects.

References

Aug 1, 1987·Archives of Biochemistry and Biophysics·F S Archibald, C Tyree

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Citations

Nov 5, 2002·Annual Review of Pharmacology and Toxicology·Richard Nass, Randy D Blakely
Jun 21, 2011·Parkinson's Disease·Kyota FujitaMami Noda
May 1, 1995·Acta Neurologica Scandinavica·F J Jiménez-JiménezE García-Albea
Mar 15, 2015·Metallomics : Integrated Biometal Science·Sudipta ChakrabortyMichael Aschner
Jan 5, 2002·International Journal of Toxicology·C S ChettyW J Slikker
Jan 1, 1991·Neurochemical Research·F F OldfieldA Y Sun
Apr 24, 2007·Neurotoxicity Research·Nicola SimolaAnna R Carta

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