Manganese-Catalyzed Carbonylative Annulations for Redox-Neutral Late-Stage Diversification

Angewandte Chemie
Yu-Feng LiangLutz Ackermann

Abstract

An inexpensive, nontoxic manganese catalyst enabled unprecedented redox-neutral carbonylative annulations under ambient pressure. The manganese catalyst outperformed all other typically used base and precious-metal catalysts. The outstanding versatility of the manganese catalysis manifold was reflected by ample substrate scope, setting the stage for effective late-stage manipulations under racemization-free conditions of a wealth of marketed drugs and natural products, including alkaloids, amino acids, steroids, and carbohydrates.

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Citations

Mar 13, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Chengniu WangFei Sun
Aug 23, 2019·Organic Letters·Shaukat AliCongyang Wang
Jul 28, 2019·The Journal of Organic Chemistry·Jian-Xing Xu, Xiao-Feng Wu
Nov 26, 2021·The Journal of Organic Chemistry·Yudong LiYuehui Li

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