Manganese-Catalyzed N-Alkylation of Sulfonamides Using Alcohols

The Journal of Organic Chemistry
Benjamin G Reed-Berendt, Louis C Morrill

Abstract

An efficient manganese-catalyzed N-alkylation of sulfonamides has been developed. This borrowing hydrogen approach employs a well-defined and bench-stable Mn(I) PNP pincer precatalyst, allowing benzylic and simple primary aliphatic alcohols to be employed as alkylating agents. A diverse range of aryl and alkyl sulfonamides undergoes mono- N-alkylation in excellent isolated yields (32 examples, 85% average yield).

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Citations

Apr 9, 2019·ChemSusChem·Mubarak B DambattaLouis C Morrill
Aug 31, 2019·Organic & Biomolecular Chemistry·Megan D HopkinsAngus A Lamar
Mar 19, 2020·Angewandte Chemie·Fabian KallmeierRhett Kempe
Feb 18, 2020·ACS Catalysis·Kurt PolidanoLouis C Morrill
Dec 6, 2019·The Journal of Organic Chemistry·Murali Mohan GuruBiplab Maji

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