Manganese-enhanced MRI optic nerve tracking: effect of intravitreal manganese dose on retinal toxicity

NMR in Biomedicine
Lisha LuoYuntao Hu

Abstract

The aim of this study was to provide data on the dose dependence of manganese-enhanced MRI (MEMRI) in the visual pathway of experimental rats and to study the toxicity of MnCl₂ to the retina. Sprague-Dawley rats were intravitreally injected with 2 μL of 0, 10, 25, 50, 75, 100, 150 and 300 mM MnCl₂, respectively. The contrast-to-noise ratio (CNR) of MEMRI for optic nerve enhancement was measured at different concentrations of MnCl₂. Simultaneously, the toxicity of manganese was evaluated by counting retinal ganglion cells and by retinal histological examination using light microscopy and transmission electron microscopy. The CNR increased with increasing concentration of MnCl₂ up to 75 mM. Retinal ganglion cell densities were reduced significantly when the concentration of MnCl₂ in the intravitreal injection was equal to or greater than 75 mM. Increasing numbers of ribosomes in retinal ganglion cells were first detected at 25 mM of MnCl₂. The retinal toxicity of MnCl₂ at higher concentration also included mitochondrial pathology and cell disruption of retinal ganglion cells, as well as abnormalities of photoreceptor and retinal pigment epithelium cells. It can be concluded that intravitreal injection of MnCl₂ induces retinal cel...Continue Reading

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Citations

May 23, 2014·Translational Neurodegeneration·Shweta ModgilAkshay Anand
Jun 18, 2014·NeuroImage·Tsen-Hsuan LinSheng-Kwei Song
Jun 12, 2018·Frontiers in Neural Circuits·Suellen Almeida-CorrêaCarsten T Wotjak

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