PMID: 8581566Sep 1, 1995Paper

Manganese-induced reactive oxygen species: comparison between Mn+2 and Mn+3

Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration
S F AliW Slikker

Abstract

Manganese (Mn) is an essential element, the deficiency or excess of which is known to cause neurotoxicity in experimental animals and man. The mechanism of action of Mn neurotoxicity is still unclear. The present study was designed to evaluate whether in vitro or in vivo exposure to Mn produced reactive oxygen species (ROS). We also sought to determine if a single injection of Mn produces changes in monoamines concentration in different regions of rat brain. Adult Sprague-Dawley rats were dosed with 0, 50 or 100 mg/kg, ip with either MnCl2 (Mn+2) or MnOAc (Mn+3) and were sacrificed 1 h after the dose was administered. Brains were quickly removed and dissected for neurochemical analysis. ROS were measured by a molecular probe, 2',7'-dichlorofluorescein diacetate (DCFH-DA), and monoamines and their metabolites were measured by HPLC/EC. In vitro exposure to MnCl2 (1-1000 microM) produced dose-dependent increases of ROS in striatum whereas MnOAc produced similar increases at much lower concentrations (1-100 microM). In vivo exposure to MnOAc (Mn+3) produced significant increases of ROS in caudate nucleus and hippocampus, whereas MnCl2 (Mn+2) produced significant effects only in hippocampus. Concentrations of dopamine, serotonin and...Continue Reading

References

Aug 1, 1987·Archives of Biochemistry and Biophysics·F S Archibald, C Tyree
Jan 1, 1974·Archives of Neurology·D G CookK A Brait
Nov 1, 1982·Canadian Journal of Physiology and Pharmacology·J DonaldsonF LaBella
Nov 17, 1994·Annals of the New York Academy of Sciences·K P MohanakumarC C Chiueh
Jan 1, 1993·Toxicology and Industrial Health·R A Floyd, J M Carney

❮ Previous
Next ❯

Citations

Oct 23, 2010·Journal of Electron Microscopy·L Colin-BarenqueT I Fortoul
Jan 18, 2012·Journal of Experimental Botany·Jelena Dragišić MaksimovićMiroslav Nikolic
Nov 6, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christoffer TammSandra Ceccatelli
Nov 14, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Thomas Jursa, Donald R Smith
Jan 15, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yue LiuBin Liu
Sep 14, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Peili HuangZhiwei Sun
Nov 3, 2009·Bioorganic & Medicinal Chemistry·Atsushi MiyazakiAkira Takai
Mar 29, 2014·Luminescence : the Journal of Biological and Chemical Luminescence·Lingling Ren, Hua Cui
Apr 24, 2004·Annals of the New York Academy of Sciences·Allison W DobsonMichael Aschner
Apr 24, 2004·Annals of the New York Academy of Sciences·Diem HaMai, Stephen C Bondy
Feb 1, 2007·BioFactors·Kevin B MillerJohn W Finley
May 1, 2007·Journal of Neuroscience Research·Daniel R CrooksDonald R Smith
Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·R B HernándezB Michalke
Dec 26, 2012·Neurochemistry International·Marcelo FarinaMichael Aschner
Feb 12, 2013·Free Radical Biology & Medicine·Ebany J Martinez-FinleyThomas E Gunter
Jun 28, 2015·Archives of Biochemistry and Biophysics·Erik BonkeStefan Dröse
Sep 10, 2003·Environmental Research·Surong ZhangJuanling Fu
Mar 23, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Lilian Calderón-GarcidueñasTomás R Guilarte
Feb 15, 2015·Brain Research·Yasaswi MaddiralaNuran Ercal
Oct 2, 2012·Toxicology and Applied Pharmacology·Kamilla Blecharz-KlinEwa Widy-Tyszkiewicz
Nov 3, 2016·Biological Trace Element Research·Saylav BoraTaner Dagcı
Jan 7, 2011·Parkinson's Disease·José Luis Ordoñez-LibradoMaria Rosa Avila-Costa
Feb 23, 2010·Brain Research·Ana Paula Marreilha dos SantosMichael Aschner
Mar 4, 2005·Critical Reviews in Toxicology·Michael AschnerDavid C Dorman
Jan 21, 2011·Journal of Environmental Monitoring : JEM·Caboche JulienLaurent Y Alleman
May 27, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Yassine ChtourouNajiba Zeghal
Sep 17, 2005·American Journal of Respiratory and Critical Care Medicine·Sung Gu HanVal Vallyathan
Feb 27, 2013·Archives of Environmental Contamination and Toxicology·Diogo GabrielSusana F Llesuy
Sep 17, 2013·Biological Trace Element Research·Akram EidiShahabeddin Safi
Mar 7, 2014·Metallomics : Integrated Biometal Science·Katharina FernsebnerBernhard Michalke
Apr 12, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Mark R Bleackley, Ross T A Macgillivray
Sep 19, 2019·Pharmaceuticals·Julia GreiserMartin Freesmeyer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.