Oct 1, 1975

Manganese mutagenesis in yeast. A practical application of manganese for the induction of mitochondrial antibiotic-resistant mutations

Journal of General Microbiology
A PutramentW Prazmo

Abstract

When yeast cells were incubated for 4 to 8 h in yeast extract-peptone-glucose medium, pH 6, containing 8 mM-manganese, and then plated on selective media, there was a strong induction of antibiotic-resistant mutations. Indirect evidence suggests that practically all resistant mutants selected were of independent origin. The analysis of manganese-induced resistant mutants showed that most were extranuclear, while those tested showed recombination with known mitochondrial markers. Our results suggest that manganese can be considered as a mutagen which specifically induces mitochondrial mutations in Saccharomyces cerevisiae.

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Mentioned in this Paper

Antibiotic Resistance, Microbial
Manganese
Bacteriocidal Agents
Recombination, Genetic
Mitochondria
Cell Division Phases
Saccharomyces cerevisiae
Hydrogen-Ion Concentration
Clastogens
Cytoplasmic Inheritance

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