Manganese regulation of veratryl alcohol in white rot fungi and its indirect effect on lignin peroxidase.

Applied and Environmental Microbiology
T MesterJ A Field

Abstract

Many white rot fungi are able to produce de novo veratryl alcohol, which is known to be a cofactor involved in the degradation of lignin, lignin model compounds, and xenobiotic pollutants by lignin peroxidase (LiP). In this study, Mn nutrition was shown to strongly influence the endogenous veratryl alcohol levels in the culture fluids of N-deregulated and N-regulated white rot fungi Bjerkandera sp. strain BOS55 and Phanerochaete chrysosporium BKM-F-1767, respectively. Endogenous veratryl alcohol levels as high as 0.75 mM in Bjerkandera sp. strain BOS55 and 2.5 mM in P. chrysosporium were observed under Mn-deficient conditions. In contrast, veratryl alcohol production was dramatically decreased in cultures supplemented with 33 or 264 (mu)M Mn. The LiP titers, which were highest in Mn-deficient media, were shown to parallel the endogenous veratryl alcohol levels, indicating that these two parameters are related. When exogenous veratryl alcohol was added to Mn-sufficient media, high LiP titers were obtained. Consequently, we concluded that Mn does not regulate LiP expression directly. Instead, LiP titers are enhanced by the increased production of veratryl alcohol. The well-known role of veratryl alcohol in protecting LiP from ina...Continue Reading

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Citations

Jul 2, 1998·Applied and Environmental Microbiology·M T MoreiraJ A Field
Jun 3, 2015·Biotechnology Progress·Roberto Taboada-PuigJuan M Lema
Sep 24, 2008·Applied Microbiology and Biotechnology·Deepak Singh, Shulin Chen
Jan 16, 2015·Applied Biochemistry and Biotechnology·J E Méndez-HernándezJ M Lema
Jan 12, 2013·Applied Biochemistry and Biotechnology·R Taboada-PuigJ M Lema
Jun 27, 2008·Applied Biochemistry and Biotechnology·Dominic W S Wong
Apr 22, 2011·Biotechnology Progress·Roberto Taboada-PuigJuan Manuel Lema
Nov 2, 2013·Journal of Applied Microbiology·A MusengiS G Burton
Oct 12, 2018·Biotechnology and Applied Biochemistry·Ayodeji O FaladeUchechukwu U Nwodo
Dec 26, 2001·Chemical Reviews·R ten Have, P J Teunissen
Aug 1, 1997·Applied and Environmental Microbiology·R ten HaveJ A Field

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