Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case-control study of African Americans and whites

Breast Cancer Research : BCR
Robert C MillikanTemitope Keku

Abstract

A polymorphism in the manganese superoxide dismutase (MnSOD) gene, Ala-9Val, has been examined in association with breast cancer risk in several epidemiologic studies. Results suggest that the Ala allele increases the risk of breast cancer and modifies the effects of environmental exposures that produce oxidative damage to DNA. We examined the role of the MnSOD Ala-9Val polymorphism in a population-based case-control study of invasive and in situ breast cancer in North Carolina. Genotypes were evaluated for 2025 cases (760 African Americans and 1265 whites) and for 1812 controls (677 African Americans and 1135 whites). The odds ratio for MnSOD Ala/Ala versus any MnSOD Val genotypes was not elevated in African Americans (odds ratio = 0.9, 95% confidence interval = 0.7-1.2) or in whites (odds ratio = 1.0, 95% confidence interval = 0.8-1.2). Greater than additive joint effects were observed for the Ala/Ala genotype and smoking, radiation to the chest, and occupational exposure to ionizing radiation. Antagonism was observed between the Ala/Ala genotype and the use of nonsteroidal anti-inflammatory drugs. The MnSOD genotype may contribute to an increased risk of breast cancer in the presence of specific environmental exposures. Thes...Continue Reading

References

Aug 15, 1991·American Journal of Epidemiology·C R Weinberg, D P Sandler
Jul 1, 1995·Breast Cancer Research and Treatment·B NewmanE T Liu
Sep 1, 1994·Environmental Health Perspectives·T M ReidL A Loeb
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·J S RosenblumR A Lerner
May 1, 1996·Epidemiology·S F AssmannK A Mundt
Jan 16, 1999·Free Radical Biology & Medicine·L L de ZwartN P Vermeulen
Feb 19, 1999·Journal of Epidemiology and Community Health·C Poole, K J Rothman
Jun 10, 2000·American Journal of Public Health·P G MoormanB Newman
Aug 31, 2000·American Journal of Epidemiology·I J HallP G Moorman
Oct 4, 2000·Nature Genetics·K M Weiss, J D Terwilliger
May 24, 2001·Archives of Biochemistry and Biophysics·L ForsbergR Morgenstern
Jun 21, 2001·Public Health Nutrition·P G MoormanB Newman
Oct 16, 2001·Nature Genetics·J P IoannidisD G Contopoulos-Ioannidis
Dec 6, 2001·Journal of the National Cancer Institute·L I WangD C Christiani
Jun 14, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Helen GreenRichard Houlston
Jun 18, 2002·Trends in Molecular Medicine·Stephen Chanock, Sholom Wacholder
Feb 25, 2003·Lancet·John P A IoannidisDespina G Contopoulos-Ioannidis
Mar 18, 2003·Molecular and Cellular Biology·Guozheng GuoJian Jian Li
Mar 19, 2003·Lancet·Helen M ColhounGeorge Davey Smith
Jun 11, 2003·American Journal of Respiratory and Critical Care Medicine·Vuokko L Kinnula, James D Crapo
Jul 2, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marcus S CookeJoseph Lunec
Jul 9, 2003·Breast Cancer Research and Treatment·Robert MillikanLynn Dressler
Sep 10, 2003·Cancer Letters·Kathleen M EganChristine B Ambrosone
May 4, 2004·International Journal of Cancer. Journal International Du Cancer·Rayjean J HungStefano Porru
Jul 28, 2011·Women's Health·Henry T Lynch, Jane F Lynch

❮ Previous
Next ❯

Citations

May 11, 2005·Journal of Cancer Research and Clinical Oncology·Malin BergmanSten Wingren
Jun 16, 2009·Bulletin of Experimental Biology and Medicine·N A KostrykinaM L Filipenko
Mar 3, 2010·Biological Trace Element Research·Olusegun I Alatise, Gerhard N Schrauzer
Oct 5, 2006·Journal of the National Cancer Institute·UNKNOWN Breast Cancer Association Consortium
Jun 11, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sharon A GlynnStefan Ambs
Jun 17, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·June M ChanPhilip W Kantoff
Sep 20, 2006·Pharmacogenomics·R L BowenL J Jones
Jun 1, 2010·Toxicological Research·Aekyong Kim
Jan 20, 2012·Free Radical Research·Arseniy E Yuzhalin, Anton G Kutikhin
May 4, 2013·Ophthalmic Genetics·Dragana CelojevicMadeleine Zetterberg
Oct 7, 2008·The Journal of Obstetrics and Gynaecology Research·Altay Burak DalanTurgay Isbir
Jan 20, 2010·Cancer Genetics and Cytogenetics·Claudia Giuliano BicaIvana Beatrice Mânica da Cruz
Jul 23, 2008·Cell Biochemistry and Function·Zorica Arsova-SarafinovskaAleksandar J Dimovski
Jun 17, 2008·Pathology Oncology Research : POR·Claudia Giuliano BicaCláudio Galleano Zettler
Dec 17, 2009·Journal of Cancer Research and Clinical Oncology·Chen MaoQing Chen
Apr 16, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·A Cecile J W JanssensCornelia M van Duijn
Mar 4, 2014·Advances in Urology·Dogan AtilganUnal Erkorkmaz
Jan 6, 2005·The Oncologist·Lisa A Newman
Dec 7, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Patrick B HamiltonCharles R Tyler
Dec 30, 2004·Nutrition Reviews·Susan A NowellChristine B Ambrosone
Mar 25, 2019·Biomedical Reports·Ayca TaşMustafa GüRelık
Jan 15, 2013·Journal of Biochemical and Molecular Toxicology·Ayşe EkenAhmet Aydin
Oct 20, 2017·Molecular and Clinical Oncology·Chengdi WangYulin Ji
May 20, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·L SunN Homann
Nov 9, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Channing J PallerMichael A Carducci
Sep 6, 2005·Cancer Research·Jeffrey A CanterRobert C Millikan
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Paul D Terry, Michael Goodman
Apr 27, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Greice Franciele Feyh dos Santos MontagnerIvana Beatrice Mânica da Cruz

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
blood draws
PCR
hormone replacement therapy
X-ray

Software Mentioned

SAS
Primer [UNK]

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Risk Factors

Breast cancer is a multifactorial disease that is influenced by both environmental and genetic factors. Discover the latest research on the environmental and genetic risk factors for breast cancer here.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.