Manganese superoxide dismutase and heat shock protein 70 are not necessary for suppression of apoptosis in human peripheral blood neutrophils

American Journal of Respiratory Cell and Molecular Biology
G CoxG W Hunninghake

Abstract

We have previously shown that granulocyte (G-CSF) and granulocyte/macrophage (GM-CSF) colony-stimulating factors present in human bronchial epithelial cell conditioned medium (HBEC-CM) suppress apoptosis in neutrophils. In this study, we demonstrate that HBEC-CM also induces increased expression of manganese superoxide dismutase (MnSOD) and heat shock protein 70 (HSP70) in neutrophils. However, treatment of neutrophils with recombinant GM-CSF and G-CSF, which suppressed apoptosis to equivalent degrees, did not induce MnSOD or HSP 70. Thus, we conclude that induction of stress proteins is associated with, but not necessary for, suppression of apoptosis.

Citations

Jan 12, 2008·The Journal of Biological Chemistry·Kimberly J AikenHarry S Nick
Apr 24, 2002·Antioxidants & Redox Signaling·Vuokko L KinnulaPirjo Koistinen
Jun 5, 2003·International Immunopharmacology·Min-Jung LeeJong-Young Kwak
Dec 1, 1996·European Journal of Immunology·Y DelnesteJ Y Bonnefoy
Oct 1, 1998·The American Journal of Physiology·M VayssierB S Polla
Jan 25, 2000·American Journal of Physiology. Cell Physiology·P Pietarinen-RunttiV L Kinnula

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