Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling.

Free Radical Biology & Medicine
Zhonghua LiuXiaofeng Zhou

Abstract

Our previous studies had revealed that the dysregulation of manganese superoxide dismutase (SOD2) expression was a frequent event in tongue squamous cell carcinoma (TSCC) and may be associated with enhanced metastatic potential. To further evaluate the mechanism of SOD2-mediated metastasis in TSCC, TSCC cell lines with different metastatic potentials (i.e., the highly metastatic UM1 line and the UM2 line, which displays fewer metastases) were used. Compared to UM2 cells, UM1 cells exhibited significantly higher SOD2 activity and intracellular H(2)O(2); higher protein levels of Snail, MMP1, and pERK1/2; lower protein levels of E-cadherin; and no difference in catalase activity. Upon knockdown of SOD2 by RNA interference, UM1 cells displayed significantly reduced migration and invasion abilities; reduced activities of SOD2; lower intracellular H(2)O(2); decreased protein levels of Snail, MMP1, and pERK1/2; and increased protein levels of E-cadherin. The migration and invasion abilities of UM2 and SOD2 shRNA-transfected UM1 cells were enhanced by H(2)O(2) treatment and accompanied by increased protein levels of Snail, MMP1, and pERK1/2 and decreased protein levels of E-cadherin. Moreover the migration and invasion abilities of UM1...Continue Reading

References

Jan 25, 2000·The Journal of Surgical Research·M MalafaM Christophersen
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christophe CômePierre Savagner
Aug 29, 2007·The American Journal of Pathology·Robert G HardyIsidro Sánchez-García
Oct 22, 2008·Free Radical Biology & Medicine·Nadine HempelJ Andres Melendez
Jan 13, 2009·Free Radical Biology & Medicine·Brian P JamesGarth Powis
Jun 10, 2009·International Journal of Cancer. Journal International Du Cancer·Isabel QuirósJuan C Mayo
Jul 7, 2009·Cardiovascular Research·Prabhakara Reddy NagareddyCarlos Fernandez-Patron
Jan 8, 2010·Molecular Cancer Therapeutics·William C ReinholdJohn N Weinstein
Nov 4, 2010·The Journal of Biological Chemistry·Mukul K MittalGautam Chaudhuri
Jan 29, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Yasuto UchikadoShoji Natsugoe
Mar 26, 2011·Anti-cancer Agents in Medicinal Chemistry·Nadine HempelJ Andres Melendez
Mar 29, 2011·American Journal of Otolaryngology·Abie H MendelsohnMaie A St John
Jun 8, 2011·International Journal of Cancer. Journal International Du Cancer·Cheng WangXiaofeng Zhou

❮ Previous
Next ❯

Citations

Feb 13, 2015·International Journal of Oncology·Sora LeeYoung Do Yoo
Jun 29, 2015·Free Radical Biology & Medicine·Christophe GlorieuxPedro Buc Calderon
Oct 24, 2013·Biochemical and Biophysical Research Communications·Mo LiuAnxun Wang
Aug 12, 2014·Biochemical Society Transactions·Anja Konzack, Thomas Kietzmann
Jan 13, 2015·The International Journal of Biochemistry & Cell Biology·Zhonghua LiuAnxun Wang
Sep 30, 2014·International Journal of Food Sciences and Nutrition·María Del Mar Roca-RodríguezFrancisco J Tinahones
Jan 26, 2017·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Muyuan JiAnxun Wang
Nov 4, 2017·Antioxidants·Yeon Soo KimNadine Hempel
Oct 18, 2019·Journal of Pediatric Psychology·Marianne J E van der HeijdenMonique van Dijk
Oct 5, 2018·The Cochrane Database of Systematic Reviews·Kathryn A BirnieJennifer A Parker
Oct 11, 2013·The Cochrane Database of Systematic Reviews·Lindsay S UmanSteve R Kisely
Jul 27, 2017·Frontiers in Cell and Developmental Biology·Rui BenfeitasAdil Mardinoglu
Sep 15, 2017·Journal of Oral Science·Sumita BanerjeePallav Singhal
Nov 18, 2018·Journal of Translational Medicine·Qinghai ZhangPeili Bu
Feb 14, 2019·Experimental & Molecular Medicine·Chan-Hun JungHong-Duck Um
Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chenxia HeMarcelo G Bonini
Sep 12, 2015·Cancer Research·L P Madhubhani P HemachandraNadine Hempel
Feb 20, 2021·Nutrition & Metabolism·Yuelin TongZhao He

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.