Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism and mood disorders: a preliminary study

Progress in Neuro-psychopharmacology & Biological Psychiatry
Chi-Un PaeIn-Ho Paik

Abstract

This study examined the relationship between a MnSOD gene (MnSOD) polymorphism (Ala-9Val) and mood disorders such as major depressive disorder (MDD) and bipolar I disorder (BD). Eighty patients with BD, 61 patients with MDD and 106 healthy controls were enrolled in this study and genotyped using a polymerase chain reaction-based method. The patients with MDD and BD, and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD polymorphism. The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD polymorphism and mood disorders. Subgroup analyses according to the clinical variables such as the family history, age at onset, psychotic features and suicide history failed to identify any association with the Ala-9Val MnSOD polymorphism. This preliminary data suggests that at least in the Korean population, the Ala-9Val MnSOD polymorphism is not associated with the development of mood disorders or their clinical parameters. However, more study with a larger population sample will be needed.

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Citations

Oct 17, 2007·Molecular Psychiatry·S López-LeónC M van Duijn
Apr 29, 2008·The Psychiatric Clinics of North America·Jelena BrezoGustavo Turecki
Jan 1, 2013·Journal of Molecular Psychiatry·Karolina FurczykAndreas Büttner
Mar 13, 2016·Psychiatry and Clinical Neurosciences·Massimiliano BuoliA Carlo Altamura
Jan 1, 2020·Molecular Genetics & Genomic Medicine·Ivo Emilio da Cruz JungMarta Maria Medeiros Frescura Duarte
Feb 6, 2020·Molecular Psychiatry·Nadine C van der BurgP Roberto Bakker
Aug 14, 2021·The International Journal of Neuropsychopharmacology·Yi ZouBenjamin I Goldstein

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