Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers

Oxidative Medicine and Cellular Longevity
Elena AlberdiCarlos Matute

Abstract

Amyloid beta- (Aβ-) mediated ROS overproduction disrupts intraneuronal redox balance and exacerbates mitochondrial dysfunction which leads to neuronal injury. Polyphenols have been investigated as therapeutic agents that promote neuroprotective effects in experimental models of brain injury and neurodegenerative diseases. The aim of this study was to identify the neuroprotective effects of morin and mangiferin against Aβ oligomers in cultured cortical neurons and organotypic slices as well as their mechanisms of action. Cell death caused by Aβ oligomers in neuronal cultures was decreased in the presence of micromolar concentrations of mangiferin or morin, which in turn attenuated oxidative stress. The neuroprotective effects of antioxidants against Aβ were associated with the reduction of Aβ-induced calcium load to mitochondria; mitochondrial membrane depolarization; and release of cytochrome c from mitochondria, a key trigger of apoptosis. Additionally, we observed that both polyphenols activated the endogenous enzymatic antioxidant system and restored oxidized protein levels. Finally, Aβ induced an impairment of energy homeostasis due to a decreased respiratory capacity that was mitigated by morin and mangiferin. Overall, the...Continue Reading

References

Mar 29, 2000·JAMA : the Journal of the American Medical Association·J NäslundJ D Buxbaum
Jun 12, 2002·The Journal of Biological Chemistry·Karie N DahlgrenMary Jo LaDu
Jul 11, 2002·Free Radical Biology & Medicine·Christian Behl, Bernd Moosmann
Mar 8, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gilberto Pardo AndreuAnibal E Vercesi
Sep 20, 2005·The Journal of Pharmacology and Experimental Therapeutics·Zhifeng YuChristopher H K Cheng
Oct 22, 2005·Annals of Neurology·William R MarkesberyJason D Morrow
Jan 13, 2006·Nature Chemical Biology·Valerian E KaganGregory G Borisenko
Feb 18, 2006·Clinical Chemistry·Isabella Dalle-DonneAldo Milzani
May 9, 2006·Biochimica Et Biophysica Acta·Vladimir GogvadzeBoris Zhivotovsky
Jun 30, 2006·Neurobiology of Disease·Miroslav GottliebCarlos Matute
Oct 19, 2006·Journal of Biomedicine & Biotechnology·Akihiko NunomuraGeorge Perry
Oct 9, 2007·Neurobiology of Disease·Mark A Lovell, William R Markesbery
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xin WangRobert M Friedlander
Feb 10, 2009·Current Alzheimer Research·Fabio Coppedè, Lucia Migliore
Feb 10, 2009·Cell Calcium·María Rosario Campos-EsparzaCarlos Matute
Jan 12, 2010·Journal of Alzheimer's Disease : JAD·M Paul Murphy, Harry LeVine
Apr 13, 2010·Nature Structural & Molecular Biology·Mahiuddin AhmedSteven O Smith
Feb 26, 2011·Cell Calcium·Laura TexidóCarlos Matute
Jul 23, 2011·Free Radical Biology & Medicine·Sergey Dikalov
Jul 26, 2011·Neurobiology of Disease·Eun Ji GongJaewon Lee
Nov 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Meagan J McManusJames L Franklin
Jan 10, 2012·Cold Spring Harbor Perspectives in Medicine·Alberto Serrano-PozoBradley T Hyman
Jun 30, 2012·Trends in Endocrinology and Metabolism : TEM·Jessica M CurtisDavid A Bernlohr
Oct 2, 2013·Current Pharmaceutical Design·Maria Cristina Polidori, Gereon Nelles
May 23, 2014·Current Biology : CB·Michael Schieber, Navdeep S Chandel
Jun 16, 2015·Frontiers in Cellular Neuroscience·Sergio T FerreiraFernanda G De Felice
Dec 18, 2015·Free Radical Biology & Medicine·Fabio Di DomenicoMarzia Perluigi
Jul 23, 2016·Molecular Neurobiology·Carmen Infante-GarciaMonica Garcia-Alloza
Sep 9, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Corina T Madreiter-SokolowskiWolfgang F Graier

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Citations

Jul 10, 2019·International Journal of Environmental Research and Public Health·Indhumathi VeerappanRajaguru Palanisamy
Apr 28, 2020·Critical Reviews in Food Science and Nutrition·Ricardo DiasRosa Perez-Gregorio
Jul 10, 2019·Oxidative Medicine and Cellular Longevity·Jian DaiKeiichi Higuchi
Mar 3, 2020·Frontiers in Synaptic Neuroscience·Carolina Ortiz-SanzElena Alberdi
Feb 13, 2019·Journal of Molecular Neuroscience : MN·Shuping DuJi Jia
Dec 22, 2020·Neurochemistry International·Vaibhav WaliaNeeraj Kumar Sethiya
Jan 19, 2021·Drug Development Research·Tingjun LiuAnkang Hu
Mar 23, 2021·Journal of Alzheimer's Disease : JAD·Roger GaudreaultCharles Ramassamy
Jul 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ping DiaoLi Li

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Methods Mentioned

BETA
transgenic
Transfection
FRET
transmission electron microscopy

Software Mentioned

ImageJ
ImageLab
Image J
Axio Vision

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