Abstract
Mangiferin has antioxidant, antiviral, apoptosis regulating, anti‑inflammatory, antitumor and antidiabetic effects, which can also inhibit osteoclast formation and bone resorption. However, whether mangiferin ameliorates the neurological pain of spinal cord injury (SCI) in ratS remains to be elucidated. The present study investigated the therapeutic effects of mangiferin on neurological function, the water content of spinal cord, oxidative stress, the expression of inflammatory cytokines and the protein expression of Bcl‑2/Bax in a SCI rat model. In the present study, the Basso, Beattie and Bresnahan scores, and the water content of the spinal cord were used to analyze the therapeutic effects of mangiferin on neurological pain in the SCI rat. The concentrations of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and the serum levels of glutathione peroxidase (GSH‑PX), nuclear factor‑κB p65 unit, tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6 and caspase‑3/9 were detected using commercial kits. The expression levels of Bcl‑2 and Bax were measured using western blot analysis. The results demonstrated that administrating mangiferin began to ameliorate neurological function and the water content of the spinal ...Continue Reading
References
Jul 1, 1996·Journal of Neurotrauma·D M BassoW Young
Mar 15, 2000·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C YoosookC Kantasuk
Jun 6, 2000·Brain Research·S K RayN L Banik
Oct 12, 2000·Cellular and Molecular Life Sciences : CMLS·P Maher, D Schubert
Oct 3, 2003·Trends in Neurosciences·Florence M Bareyre, Martin E Schwab
Feb 18, 2005·Journal of Neurotrauma·R RavikumarMichal Toborek
Aug 10, 2006·Cellular and Molecular Neurobiology·Dasa CízkováMilan Cízek
Nov 7, 2006·Neuropharmacology·Yan-Ling LiuXian-Guo Liu
Sep 26, 2008·Basic & Clinical Pharmacology & Toxicology·Peramaiyan RajendranDhanapal Sakthisekaran
Feb 10, 2009·Cell Calcium·María Rosario Campos-EsparzaCarlos Matute
Aug 8, 2009·Progress in Brain Research·Jessica K Alexander, Phillip G Popovich
Feb 13, 2010·Human & Experimental Toxicology·E Kasi ViswanadhB S Satish Rao
Mar 20, 2010·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hui LinHaixia Zhang
Jul 16, 2010·Environmental Toxicology·Sobhika AgarwalaB S Satish Rao
Dec 15, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bárbara B Garrido-SuárezMaría del C Rabí
Mar 23, 2011·Cancer Letters·Dagmar García-RiveraWim Vanden Berghe
Apr 13, 2011·World Journal of Gastroenterology : WJG·Wei-Li QiaoChang-Dong Yan
Nov 15, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Hussain Al DeraJames A Brock
Nov 29, 2011·Free Radical Research·Manoranjan GhoshParames C Sil
Jan 6, 2012·World Journal of Gastroenterology : WJG·Giovanni TarantinoSilvia Savastano
Jul 4, 2012·Immunobiology·Pía M VidalSven Hendrix
Dec 26, 2012·The Journal of Nutritional Biochemistry·Xia GongJingyuan Wan
Feb 26, 2013·The Journal of Spinal Cord Medicine·Esmat MohammadiSoheila Rahgozar
Mar 2, 2013·PloS One·Pabitra Bikash PalParames C Sil
Jul 3, 2013·Archives of Physical Medicine and Rehabilitation·Francisco J OrdonezManuel Rosety-Rodriguez
Jul 17, 2013·Spinal Cord·T LamA A Al-Yahya
Jul 19, 2013·Journal of Molecular Neuroscience : MN·Maosheng Xia, Yue Zhu
Oct 8, 2013·Chemico-biological Interactions·Mani KavithaThamilarasan Manivasagam
Oct 30, 2013·ISRN Pharmacology·Periyar Selvam SellamuthuMurugesan Kandasamy
Dec 4, 2013·Journal of Neurotrauma·Jee Y LeeTae Y Yune
Mar 14, 2014·The Journal of Spinal Cord Medicine·Hongbin NiZhengliang Ma
Apr 29, 2014·Molecular and Clinical Oncology·Yanfeng LiuMei Zhang
Jun 19, 2014·Experimental and Therapeutic Medicine·Bingzhou CuiBo Wang
Jun 28, 2014·Molecular Medicine Reports·Jingwu LiaoYueming Song
Aug 26, 2014·Neuroscience Letters·Baohong YuanXiaonan Liu
Sep 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Li PanMin Ling
Sep 23, 2014·Drug Research·W ZhangL Nie
Citations
Jul 6, 2017·Pharmaceuticals·Angela FaccendiniFranca Ferrari
Nov 19, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xuehong LiuMarong Fang
Feb 20, 2018·Cell Proliferation·Yi LuYu Hu
Oct 25, 2016·BioFactors·Sukanya SahaParames C Sil
Dec 6, 2017·Molecular Medicine Reports·Zhong CaoTao Peng
Apr 30, 2016·AAPS PharmSciTech·Hao LiQi Wang
Aug 8, 2018·Molecular and Cellular Biochemistry·Anil Kumar SahuJagriti Bhatia
Oct 3, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Fansu MengQingqing Huang
Jun 25, 2016·Journal of Physiology and Biochemistry·Guodong WangTan Lu
Sep 26, 2017·Molecular Medicine Reports·Yang Lei
Feb 28, 2018·International Journal of Molecular Medicine·Ling-Zhi DingShi-Hong Chen
Jul 4, 2018·Frontiers in Pharmacology·Pritam SadhukhanParames C Sil
Feb 10, 2017·Scientific Reports·Kapil SuchalDharamvir Singh Arya
Dec 24, 2018·Microscopy Research and Technique·Xuehong LiuMarong Fang
Sep 11, 2019·Physical Therapy·Yue ZhouYongming Sun
Dec 8, 2020·Ultrastructural Pathology·Dalia A MohamedShaimaa Abdelrahaman
Dec 22, 2020·Neurochemistry International·Vaibhav WaliaNeeraj Kumar Sethiya
Jan 20, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Suhuan MeiXiumin Chen
Jun 9, 2021·Neural Regeneration Research·Yan ZhouYan-Jie Jia
Jul 9, 2021·Oxidative Medicine and Cellular Longevity·Haichao YuLei Cheng
Apr 13, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Renbo LiGuanjun Tu