Mangiferin protects against ‭intestinal ischemia/reperfusion-induced ‭liver injury: ‬‬Involvement of PPAR-‭γ, GSK-3β and Wnt/β-catenin pathway‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬

European Journal of Pharmacology
Shorouk M El-SayyadHanan Salah El-Abhar

Abstract

Mangiferin (MF), a xanthonoid from Mangifera indica, possesses anti-inflammatory, immunomodulatory, and potent antioxidant effects; however, its protective effect against mesenteric ischemia/reperfusion (I/R)-induced liver injury has not been fully clarified. The study was designed to assess the possible mechanism of action of MF against mesenteric I/R model. Male Wister rats were treated with MF (20mg/kg, i.p) or the vehicle for 3 days before I/R, which was induced by clamping the superior mesenteric artery for 30min followed by declamping for 60min. The mechanistic studies revealed that MF protected the 2 organs studied, viz., liver and intestine partly via increasing the content of β-catenin and PPAR-γ along with decreasing that of GSK-3β and the phosphorylated NF-қB-p65. MF antioxidant effect was evidenced by increasing contents of total antioxidant capacity and GST, besides normalizing that of MDA. Regarding the anti-inflammatory effect, MF reduced IL-1β and IL-6, effects that were mirrored on the tissue content of MPO. Moreover, MF possessed anti-apoptotic character evidenced by elevating Bcl-2 content and reducing that of caspase-3. In the serum, intestinal I/R increased the activity of ALT, AST, and creatine kinase. The...Continue Reading

Citations

Aug 30, 2017·Journal of Medicinal Food·Eli Mireya Sandoval-GallegosRaquel Cariño-Cortés
May 20, 2020·Journal of Complementary & Integrative Medicine·Saurabh MittalSanjula Baboota
Jan 20, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Suhuan MeiXiumin Chen
Mar 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jun WangGuosheng Wu
May 18, 2021·Frontiers in Pharmacology·Ruizhen HuangHonglin Hu
Jun 17, 2021·The Journal of Pharmacology and Experimental Therapeutics·Huijiao LinShu Jing

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