Mangiferin suppresses allergic asthma symptoms by decreased Th9 and Th17 responses and increased Treg response

Molecular Immunology
Chen-Xia YunHong-Wei Guo

Abstract

Mangiferin is the major bioactive ingredient in the leaves of Mangifera indica L., Aqueous extract of such leaves have been traditionally used as an indigenous remedy for respiratory diseases including cough and asthma in Traditional Chinese Medicine. Mangiferin was shown to exert its anti-asthmatic effect by modulating Th1/Th2 cytokines imbalance via STAT6 signaling pathway. However, compelling evidence indicated that subtypes of T helpers and regulatory T cells other than Th1/Th2 were also involved in the pathogenesis of asthma. In current study, we investigated the effects of mangiferin on the differentiation and function of Th9, Th17 and Treg cells in a chicken egg ovalbumin (OVA)-induced asthmatic mouse model. Mangiferin significantly attenuated the symptoms of asthma attacks, reduced the total number of leukocytes, EOS and goblet cells infiltration in lung. Simultaneously, treatment with mangiferin remarkably decreased the proportion of Th9 and Th17 cells; reduced the levels of IL-9, IL-17A; inhibited the expression of PU.1 and RORγt in lung. However, the proportion of Treg cells, the expression of IL-10, TGF-β1 and Foxp3 were increased by mangiferin. Our data suggest that mangiferin exerted anti-asthmatic effect through ...Continue Reading

Citations

Oct 20, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Fei HuangYa-Nan Li
Nov 14, 2020·Journal of Ethnopharmacology·Jun-Xi LiuJun Liang
Jan 20, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Suhuan MeiXiumin Chen
Jan 12, 2021·Frontiers in Pharmacology·Natalie Vivien GunterSiau Hui Mah

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