Mangosteen pericarp extract embedded in electrospun PVP nanofiber mats: physicochemical properties and release mechanism of α-mangostin

International Journal of Nanomedicine
Ida SriyantiKhairurrijal Khairurrijal

Abstract

α-Mangostin is a major active compound of mangosteen (Garcinia mangostana L.) pericarp extract (MPE) that has potent antioxidant activity. Unfortunately, its poor aqueous solubility limits its therapeutic application. Purpose: This paper reports a promising approach to improve the clinical use of this substance through electrospinning technique. Polyvinylpyrrolidone (PVP) was explored as a hydrophilic matrix to carry α-mangostin in MPE. Physicochemical properties of MPE:PVP nanofibers with various extract-to-polymer ratios were studied, including morphology, size, crystallinity, chemical interaction, and thermal behavior. Antioxidant activity and the release of α-mangostin, as the chemical marker of MPE, from the resulting fibers were investigated. It was obtained that the MPE:PVP nanofiber mats were flat, bead-free, and in a size range of 387-586 nm. Peak shifts in Fourier-transform infrared spectra of PVP in the presence of MPE suggested hydrogen bond formation between MPE and PVP. The differential scanning calorimetric study revealed a noticeable endothermic event at 119°C in MPE:PVP nanofibers, indicating vaporization of moisture residue. This confirmed hygroscopic property of PVP. The absence of crystalline peaks of MPE at...Continue Reading

Citations

Aug 26, 2020·Journal of Tissue Engineering and Regenerative Medicine·Parichehr Fatehi, Marjan Abbasi
Apr 14, 2020·Nanotechnology, Science and Applications·Nasrul WathoniMuchtaridi Muchtaridi
Feb 16, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Namratha Turuvekere Vittala MurthyHarsh Chauhan
Apr 4, 2021·Vaccines·Sasheen DowlathVernon K Ward

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