PMID: 11901356Mar 20, 2002Paper

Manic-depressive illness: an association study with the inositol polyphosphate 1-phosphatase and serotonin transporter genes

Psychiatric Genetics
Maria Paola PiccardiMaria Del Zompo

Abstract

Association studies with candidate genes may contribute towards the understanding of the etiopathogenesis of bipolar disorder. Candidate genes in bipolar disorders are those related to aminergic neurotransmission, which is the target of the effects of antipsychotics and antidepressants, as well as genes related to signal transduction pathways, reporting the target for the mood-stabilizing effects of lithium. Association with such candidate genes may provide clues towards the understanding of the biological components of bipolar disorder. An association study was performed between the 5' regulatory region of the serotonin transporter gene (5-HTTLPR), the inositol polyphosphate 1-phosphatase gene (INPP1) and bipolar disorder using our sample of proband/parent trios. A total of 101 bipolar probands were considered eligible for the study. Since both parents had to be available, mean age at onset of bipolar disorder in probands was relatively young. However, the mean duration of illness and the number of episodes were consistent with a stable diagnosis. In our trios sample, the transmission disequilibrium test revealed no preferential transmission of alleles of the 5-HTTLPR and INPP1 from heterozygous parents to probands. Therefore,...Continue Reading

References

Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Oct 1, 1989·The American Journal of Psychiatry·J M BarabanS H Snyder
Jul 1, 1995·Archives of General Psychiatry·H K ManjiR H Lenox
Mar 26, 1998·American Journal of Medical Genetics·L E EsterlingS D Detera-Wadleigh
Jan 19, 1999·The American Journal of Psychiatry·J B VincentJ L Kennedy

❮ Previous
Next ❯

Citations

Feb 19, 2014·Pharmacology, Biochemistry, and Behavior·Adem CanTodd D Gould
Mar 5, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E JiménezA Benabarre
Aug 20, 2004·Psychiatric Genetics·Francis E Lotrich, Bruce G Pollock
Dec 19, 2007·The Journal of Continuing Education in the Health Professions·Albert YeungElizabeth V Albert
Jan 5, 2018·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Alberto Bocchetta, Francesco Traccis
Nov 26, 2003·Psychiatric Genetics·Patrick Vourc'hChristian Andres
Dec 27, 2019·Current Drug Research Reviews·Nobue KitanakaJunichi Kitanaka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here