Manic depressive illness and tyrosine hydroxylase gene: linkage heterogeneity and association

Neurobiology of Disease
A MalafosseJ Mallet

Abstract

Several studies have implicated the tyrosine hydroxylase (TH) locus within the 11p15 region in susceptibility to manic depressive illness (MDI). This possibility was further investigated by both parametric (lod score) and nonparametric (affected-pedigree-member and a case-control study) methods of analysis in 11 French MDI families and in a sample of 200 unrelated subjects. Both types of analyses corroborate the implication of this locus, and positive lod scores were obtained in two families, which most likely reflects genetic heterogeneity. Statistical analyses were also performed including available data from published reports. These analyses, which allowed for genetic heterogeneity, substantiated our findings. The combined maximum lod score for all the families studied was 3.68 at theta = 0.00 (number of families: 36) assuming heterogeneity (alpha = 15%, P = 0.01). Taken together these results converge to suggest that the risk factors for MDI lie in the 11p15 region with TH being the most likely candidate gene.

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Citations

Mar 20, 2001·Bipolar Disorders·J B Potash, J R DePaulo
Feb 24, 2009·Journal of Psychiatric Research·Christa HercherNaguib Mechawar
May 15, 2010·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Maria Del ZompoRolando Meloni
Apr 23, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Peter P ZandiUNKNOWN National Institute of Mental Health Genetics Initiative Bipolar Group
Jul 12, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Meric A Altinoz, Bahri Ince

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